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10.1371/journal.pone.0179218 http://scihub22266oqcxt.onion/10.1371/journal.pone.0179218 C5470705!5470705!28614373     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       PLoS+One 2017 ; 12 (6): ä Nephropedia Template TP {{tp|p=28614373|t=2017. Relationship between microRNA-146a expression and plasma renalase levels in hemodialyzed patients |pdf=|usr=}}{{28614373}} gab.com Text Relationship between microRNA-146a expression and plasma renalase levels in hemodialyzed patients JO: PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=28614373 #FOAvip Background: microRNA (miRNA) belongs to the non-coding RNAs family responsible for the regulation of gene expression. Renalase is a protein composed of 342 amino acids, secreted by the kidneys and possibly plays an important role in the regulation of sympathetic tone and blood pressure. The aim of the present study was to investigate plasma renalase concentration, and explore the relationship between miRNA-146a-5p expression and plasma renalase levels in hemodialyzed patients. Methods: The study population comprised 55 subjects who succumbed to various cardiac events, 27 women and 28 men, aged 65?70 years. The total RNA including miRNA fraction was isolated using QiagenmiRNEasy Serum/Plasma kit according to the manufacturer?s protocol. The isolated miRNAs were analyzed using a quantitative polymerase chain reaction (qRT-PCR) technique. The plasma renalase levels were measured using a commercial ELISA kit. Results: In the group of patients with high levels of renalase, higher miRNA-146a expression was found, compared with those with low concentration of renalase. Patients with simultaneous low miRNA-146a expression and high level of renalase were confirmed to deliver a significantly longer survival time compared with other patients. Conclusions: miRNA-146a and plasma renalase levels were estimated as independent prognostic factors of hemodialyzed patients? survival time. Patients with low miRNA-146a expression demonstrated a significantly longer survival time in contrast to the patients with a high expression level of miRNA-146a. Moreover, a significantly longer survival time was found in patients with high renalase activity compared with patients with low activity of the enzyme. Twit Text FOAVip Relationship between microRNA-146a expression and plasma renalase levels in hemodialyzed patients ????PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=28614373 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28614373 #FOAvip English Wikipedia <ref>{{Cite pmid|28614373}}</ref> Relationship between microRNA-146a expression and plasma renalase levels in hemodialyzed patients #MMPMID28614373 Dziedzic M; Powrózek T; Or?owska E; Koch W; Kukula-Koch W; Gawe? K; Bednarek-Skublewska A; Ma?ecka-Massalska T; Milanowski J; Petkowicz B; Solski J PLoS One 2017[]; 12 (6): ä PMID28614373show ga Background: microRNA (miRNA) belongs to the non-coding RNAs family responsible for the regulation of gene expression. Renalase is a protein composed of 342 amino acids, secreted by the kidneys and possibly plays an important role in the regulation of sympathetic tone and blood pressure. The aim of the present study was to investigate plasma renalase concentration, and explore the relationship between miRNA-146a-5p expression and plasma renalase levels in hemodialyzed patients. Methods: The study population comprised 55 subjects who succumbed to various cardiac events, 27 women and 28 men, aged 65?70 years. The total RNA including miRNA fraction was isolated using QiagenmiRNEasy Serum/Plasma kit according to the manufacturer?s protocol. The isolated miRNAs were analyzed using a quantitative polymerase chain reaction (qRT-PCR) technique. The plasma renalase levels were measured using a commercial ELISA kit. Results: In the group of patients with high levels of renalase, higher miRNA-146a expression was found, compared with those with low concentration of renalase. Patients with simultaneous low miRNA-146a expression and high level of renalase were confirmed to deliver a significantly longer survival time compared with other patients. Conclusions: miRNA-146a and plasma renalase levels were estimated as independent prognostic factors of hemodialyzed patients? survival time. Patients with low miRNA-146a expression demonstrated a significantly longer survival time in contrast to the patients with a high expression level of miRNA-146a. Moreover, a significantly longer survival time was found in patients with high renalase activity compared with patients with low activity of the enzyme. äRelationship between microRNA-146a expression and plasma renalase leve(epmc).pdf DeepDyve Pubget Overpricing