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10.1016/j.cbpa.2014.09.019

http://scihub22266oqcxt.onion/10.1016/j.cbpa.2014.09.019
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C5470636!5470636!25282524
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suck abstract from ncbi

pmid25282524      Curr+Opin+Chem+Biol 2014 ; 22 (ä): 56-61
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  • Mirror Image Proteins #MMPMID25282524
  • Zhao L; Lu W
  • Curr Opin Chem Biol 2014[Oct]; 22 (ä): 56-61 PMID25282524show ga
  • Proteins composed entirely of unnatural D-amino acids and the achiral amino acid glycine are mirror image forms of their native L-protein counterparts. Recent advances in chemical protein synthesis afford unique and facile synthetic access to domain-sized mirror image D-proteins, enabling protein research to be conducted through ?the looking glass? and in a way previously unattainable. D-proteins can facilitate structure determination of their native L-forms that are difficult to crystallize (racemic X-ray crystallography); D-proteins can serve as the bait for library screening to ultimately yield pharmacologically superior D-peptide/D-protein therapeutics (mirror image phage display); D-proteins can also be used as a powerful mechanistic tool for probing molecular events in biology. This review examines recent progress in the application of mirror image proteins to structural biology, drug discovery, and immunology.
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