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10.1186/s13059-017-1240-0

http://scihub22266oqcxt.onion/10.1186/s13059-017-1240-0
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C5470267!5470267!28615035
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suck abstract from ncbi


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pmid28615035      Genome+Biol 2017 ; 18 (ä): ä
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  • Unexpected consequences: exon skipping caused by CRISPR-generated mutations #MMPMID28615035
  • Sharpe JJ; Cooper TA
  • Genome Biol 2017[]; 18 (ä): ä PMID28615035show ga
  • A new study finds that splicing disruption is a frequent consequence of mutations generated by CRISPR/Cas9 gene-editing technology, and alleles designed to be null can express aberrant proteins. This new information allows enhanced quality control procedures to select the best mutant alleles generated by CRISPR/Cas9.Please see related Method article: https://www.doi.org/10.1186/s13059-017-1237-8
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