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10.1016/j.stemcr.2017.04.020 http://scihub22266oqcxt.onion/10.1016/j.stemcr.2017.04.020 C5470077!5470077!28528697     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Stem+Cell+Reports 2017 ; 8 (6): 1488-96 Nephropedia Template TP {{tp|p=28528697|t=2017. An Embryonic Stem Cell-Specific NuRD Complex Functions through Interaction with WDR5 |pdf=|usr=}}{{28528697}} gab.com Text An Embryonic Stem Cell-Specific NuRD Complex Functions through Interaction with WDR5 JO: Stem Cell Reports http://www.kidney.de/pget.php?&tw=1&pmid=28528697 #FOAvip The Nucleosome Remodeling and Deacetylase (NuRD) complex is a chromatin regulatory complex that functions as a transcriptional co-repressor in metazoans. The NuRD subunit MBD3 is essential for targeting and assembly of a functional NuRD complex as well as embryonic stem cell (ESC) pluripotency. Three MBD3 isoforms (MBD3A, MBD3B, and MBD3C) are expressed in mouse. Here, we find that the MBD3C isoform contains a unique 50-amino-acid N-terminal region that is necessary for MBD3C to specifically interact with the histone H3 binding protein WDR5. Domain analyses of WDR5 reveal that the H3 binding pocket is required for interaction with MBD3C. We find that while Mbd3c knockout ESCs differentiate normally, MBD3C is redundant with the MBD3A and MBD3B isoforms in regulation of gene expression, with the unique MBD3C N terminus required for this redundancy. Together, our data characterize a unique NuRD complex variant that functions specifically in ESCs. Twit Text FOAVip An Embryonic Stem Cell-Specific NuRD Complex Functions through Interaction with WDR5 ????Stem Cell Reports http://www.kidney.de/pget.php?&tw=1&pmid=28528697 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28528697 #FOAvip English Wikipedia <ref>{{Cite pmid|28528697}}</ref> An Embryonic Stem Cell-Specific NuRD Complex Functions through Interaction with WDR5 #MMPMID28528697 Ee LS; McCannell KN; Tang Y; Fernandes N; Hardy WR; Green MR; Chu F; Fazzio TG Stem Cell Reports 2017[Jun]; 8 (6): 1488-96 PMID28528697show ga The Nucleosome Remodeling and Deacetylase (NuRD) complex is a chromatin regulatory complex that functions as a transcriptional co-repressor in metazoans. The NuRD subunit MBD3 is essential for targeting and assembly of a functional NuRD complex as well as embryonic stem cell (ESC) pluripotency. Three MBD3 isoforms (MBD3A, MBD3B, and MBD3C) are expressed in mouse. Here, we find that the MBD3C isoform contains a unique 50-amino-acid N-terminal region that is necessary for MBD3C to specifically interact with the histone H3 binding protein WDR5. Domain analyses of WDR5 reveal that the H3 binding pocket is required for interaction with MBD3C. We find that while Mbd3c knockout ESCs differentiate normally, MBD3C is redundant with the MBD3A and MBD3B isoforms in regulation of gene expression, with the unique MBD3C N terminus required for this redundancy. Together, our data characterize a unique NuRD complex variant that functions specifically in ESCs. äAn Embryonic Stem Cell-Specific NuRD Complex Functions through Interac(epmc).pdf DeepDyve Pubget Overpricing