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10.1155/2017/7208318 http://scihub22266oqcxt.onion/10.1155/2017/7208318 C5470022!5470022!28642868     free     free     free Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Int+J+Genomics 2017 ; 2017 (ä): ä Nephropedia Template TP {{tp|p=28642868|t=2017. An Exploration of Gene-Gene Interactions and Their Effects on Hypertension |pdf=|usr=}}{{28642868}} gab.com Text An Exploration of Gene-Gene Interactions and Their Effects on Hypertension JO: Int J Genomics http://www.kidney.de/pget.php?&tw=1&pmid=28642868 #FOAvip Hypertension tends to perpetuate in families and the heritability of hypertension is estimated to be around 20?60%. So far, the main proportion of this heritability has not been found by single-locus genome-wide association studies. Therefore, the current study explored gene-gene interactions that have the potential to partially fill in the missing heritability. A two-stage discovery-confirmatory analysis was carried out in the Framingham Heart Study cohorts. The first stage was an exhaustive pairwise search performed in 2320 early-onset hypertensive cases with matched normotensive controls from the offspring cohort. Then, identified gene-gene interactions were assessed in an independent set of 694 subjects from the original cohort. Four unique gene-gene interactions were found to be related to hypertension. Three detected genes were recognized by previous studies, and the other 5 loci/genes (MAN1A1, LMO3, NPAP1/SNRPN, DNAL4, and RNA5SP455/KRT8P5) were novel findings, which had no strong main effect on hypertension and could not be easily identified by single-locus genome-wide studies. Also, by including the identified gene-gene interactions, more variance was explained in hypertension. Overall, our study provides evidence that the genome-wide gene-gene interaction analysis has the possibility to identify new susceptibility genes, which can provide more insights into the genetic background of blood pressure regulation. Twit Text FOAVip An Exploration of Gene-Gene Interactions and Their Effects on Hypertension ????Int J Genomics http://www.kidney.de/pget.php?&tw=1&pmid=28642868 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28642868 #FOAvip English Wikipedia <ref>{{Cite pmid|28642868}}</ref> An Exploration of Gene-Gene Interactions and Their Effects on Hypertension #MMPMID28642868 Meng Y; Groth S; Quinn JR; Bisognano J; Wu TT Int J Genomics 2017[]; 2017 (ä): ä PMID28642868show ga Hypertension tends to perpetuate in families and the heritability of hypertension is estimated to be around 20?60%. So far, the main proportion of this heritability has not been found by single-locus genome-wide association studies. Therefore, the current study explored gene-gene interactions that have the potential to partially fill in the missing heritability. A two-stage discovery-confirmatory analysis was carried out in the Framingham Heart Study cohorts. The first stage was an exhaustive pairwise search performed in 2320 early-onset hypertensive cases with matched normotensive controls from the offspring cohort. Then, identified gene-gene interactions were assessed in an independent set of 694 subjects from the original cohort. Four unique gene-gene interactions were found to be related to hypertension. Three detected genes were recognized by previous studies, and the other 5 loci/genes (MAN1A1, LMO3, NPAP1/SNRPN, DNAL4, and RNA5SP455/KRT8P5) were novel findings, which had no strong main effect on hypertension and could not be easily identified by single-locus genome-wide studies. Also, by including the identified gene-gene interactions, more variance was explained in hypertension. Overall, our study provides evidence that the genome-wide gene-gene interaction analysis has the possibility to identify new susceptibility genes, which can provide more insights into the genetic background of blood pressure regulation. äAn Exploration of Gene-Gene Interactions and Their Effects on Hyperten(epmc).pdf DeepDyve Pubget Overpricing