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2017 ; 31
(3
): 230-239
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Polypoidal Choroidal Vasculopathy with Feeder Vessels: Characteristics, Fellow
Eye Findings, and Long-term Treatment Outcomes
#MMPMID28534339
Hwang HJ
; Kim JH
; Chang YS
; Kim JW
; Kim CG
Korean J Ophthalmol
2017[Jun]; 31
(3
): 230-239
PMID28534339
show ga
PURPOSE: To evaluate the long-term outcomes of anti-vascular endothelial growth
factor (VEGF) therapy for polypoidal choroidal vasculopathy (PCV) with feeder
vessels and to investigate fellow-eye findings. METHODS: This retrospective
observational study included 14 eyes with treatment-naïve PCV accompanied by
feeder vessels that were treated with anti-VEGF monotherapy. The best-corrected
visual acuity (BCVA) at baseline was compared with that at the last follow-up.
The fellow-eye indocyanine green angiography findings were also analyzed.
RESULTS: The mean follow-up period was 28.1 ± 19.2 months (range, 12 to 60
months). During the follow-up period, 5.9 ± 2.5 anti-VEGF injections were
administered. The logarithm of the minimal angle of resolution (logMAR) BCVAs at
the time of diagnosis, at 3 months, and at the last follow-up were 0.81 ± 0.49,
0.55 ± 0.44, and 0.71 ± 0.54, respectively. Although the BCVA at the last
follow-up was not different from the baseline value (p=0.809), an improvement of
?0.2 logMAR BCVA was observed in seven eyes (50.0%). In 11 eyes that underwent
bilateral indocyanine green angiography at diagnosis, PCV, branching vascular
networks, and late geographic hyperfluorescence were noted in two (18.2%), five
(45.4%), and three (27.3%) fellow eyes, respectively. During the follow-up
period, the development of polypoidal lesions in the fellow eye was observed in
three patients. CONCLUSIONS: In this study, long-term improvement in BCVA was
noted in 50% of the included patients who received anti-VEGF monotherapy. A
relatively high incidence of pathological findings in the fellow eye and
bilateral involvement suggest the need for bilateral examinations.