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10.3341/kjo.2016.0035

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suck abstract from ncbi


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pmid28534339
      Korean+J+Ophthalmol 2017 ; 31 (3 ): 230-239
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  • Polypoidal Choroidal Vasculopathy with Feeder Vessels: Characteristics, Fellow Eye Findings, and Long-term Treatment Outcomes #MMPMID28534339
  • Hwang HJ ; Kim JH ; Chang YS ; Kim JW ; Kim CG
  • Korean J Ophthalmol 2017[Jun]; 31 (3 ): 230-239 PMID28534339 show ga
  • PURPOSE: To evaluate the long-term outcomes of anti-vascular endothelial growth factor (VEGF) therapy for polypoidal choroidal vasculopathy (PCV) with feeder vessels and to investigate fellow-eye findings. METHODS: This retrospective observational study included 14 eyes with treatment-naïve PCV accompanied by feeder vessels that were treated with anti-VEGF monotherapy. The best-corrected visual acuity (BCVA) at baseline was compared with that at the last follow-up. The fellow-eye indocyanine green angiography findings were also analyzed. RESULTS: The mean follow-up period was 28.1 ± 19.2 months (range, 12 to 60 months). During the follow-up period, 5.9 ± 2.5 anti-VEGF injections were administered. The logarithm of the minimal angle of resolution (logMAR) BCVAs at the time of diagnosis, at 3 months, and at the last follow-up were 0.81 ± 0.49, 0.55 ± 0.44, and 0.71 ± 0.54, respectively. Although the BCVA at the last follow-up was not different from the baseline value (p=0.809), an improvement of ?0.2 logMAR BCVA was observed in seven eyes (50.0%). In 11 eyes that underwent bilateral indocyanine green angiography at diagnosis, PCV, branching vascular networks, and late geographic hyperfluorescence were noted in two (18.2%), five (45.4%), and three (27.3%) fellow eyes, respectively. During the follow-up period, the development of polypoidal lesions in the fellow eye was observed in three patients. CONCLUSIONS: In this study, long-term improvement in BCVA was noted in 50% of the included patients who received anti-VEGF monotherapy. A relatively high incidence of pathological findings in the fellow eye and bilateral involvement suggest the need for bilateral examinations.
  • |Aged [MESH]
  • |Angiogenesis Inhibitors/administration & dosage [MESH]
  • |Choroid Diseases/*diagnosis/drug therapy [MESH]
  • |Choroid/*blood supply/pathology [MESH]
  • |Female [MESH]
  • |Fluorescein Angiography/*methods [MESH]
  • |Follow-Up Studies [MESH]
  • |Fundus Oculi [MESH]
  • |Humans [MESH]
  • |Intravitreal Injections [MESH]
  • |Male [MESH]
  • |Polyps/*diagnosis/drug therapy [MESH]
  • |Ranibizumab/*administration & dosage [MESH]
  • |Retrospective Studies [MESH]
  • |Time Factors [MESH]
  • |Tomography, Optical Coherence/*methods [MESH]


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