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10.1038/s41598-017-03676-y http://scihub22266oqcxt.onion/10.1038/s41598-017-03676-y C5469778!5469778!28611390     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Rep 2017 ; 7 (ä): ä Nephropedia Template TP {{tp|p=28611390|t=2017. Protective and therapeutic effect of felodipine against bleomycin-induced pulmonary fibrosis in mice |pdf=|usr=}}{{28611390}} gab.com Text Protective and therapeutic effect of felodipine against bleomycin-induced pulmonary fibrosis in mice JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28611390 #FOAvip Idiopathic pulmonary fibrosis (IPF) involves alveolar epithelial injury and abnormal collagen production caused by activated fibroblasts; transforming growth factor (TGF)-?1 is implicated in this activation. In this study, we screened for chemicals capable of inhibiting TGF-?1-induced collagen production in cultured fibroblasts from medicines already in clinical use. We selected felodipine based on its extent of collagen production inhibition, clinical safety profile, and other pharmacological activity. Felodipine is a dihydropyridine Ca2+ channel blocker that has been used clinically to treat patients with high blood pressure. Felodipine suppressed collagen production within LL29 cells in the presence of TGF-?1, but not in its absence. Intratracheal administration of felodipine prevented bleomycin-induced pulmonary fibrosis, alteration of lung mechanics and respiratory dysfunction. Felodipine also improved pulmonary fibrosis, as well as lung and respiratory function when administered after fibrosis development. Furthermore, administration of felodipine suppressed a bleomycin-induced increase in activated fibroblasts in the lung. We also found other dihydropyridine Ca2+ channel blockers (nifedipine and benidipine) inhibited collagen production in vitro and partially prevented bleomycin-induced pulmonary fibrosis, alteration of lung mechanics and respiratory dysfunction in vivo. We propose that these Ca2+ channel blockers may be therapeutically beneficial for IPF patients. Twit Text FOAVip Protective and therapeutic effect of felodipine against bleomycin-induced pulmonary fibrosis in mice ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28611390 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28611390 #FOAvip English Wikipedia <ref>{{Cite pmid|28611390}}</ref> Protective and therapeutic effect of felodipine against bleomycin-induced pulmonary fibrosis in mice #MMPMID28611390 Tanaka Ki; Niino T; Ishihara T; Takafuji A; Takayama T; Kanda Y; Sugizaki T; Tamura F; Kurotsu S; Kawahara M; Mizushima T Sci Rep 2017[]; 7 (ä): ä PMID28611390show ga Idiopathic pulmonary fibrosis (IPF) involves alveolar epithelial injury and abnormal collagen production caused by activated fibroblasts; transforming growth factor (TGF)-?1 is implicated in this activation. In this study, we screened for chemicals capable of inhibiting TGF-?1-induced collagen production in cultured fibroblasts from medicines already in clinical use. We selected felodipine based on its extent of collagen production inhibition, clinical safety profile, and other pharmacological activity. Felodipine is a dihydropyridine Ca2+ channel blocker that has been used clinically to treat patients with high blood pressure. Felodipine suppressed collagen production within LL29 cells in the presence of TGF-?1, but not in its absence. Intratracheal administration of felodipine prevented bleomycin-induced pulmonary fibrosis, alteration of lung mechanics and respiratory dysfunction. Felodipine also improved pulmonary fibrosis, as well as lung and respiratory function when administered after fibrosis development. Furthermore, administration of felodipine suppressed a bleomycin-induced increase in activated fibroblasts in the lung. We also found other dihydropyridine Ca2+ channel blockers (nifedipine and benidipine) inhibited collagen production in vitro and partially prevented bleomycin-induced pulmonary fibrosis, alteration of lung mechanics and respiratory dysfunction in vivo. We propose that these Ca2+ channel blockers may be therapeutically beneficial for IPF patients. äProtective and therapeutic effect of felodipine against bleomycin-indu(epmc).pdf DeepDyve Pubget Overpricing