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10.1101/sqb.2016.81.031096 http://scihub22266oqcxt.onion/10.1101/sqb.2016.81.031096 C5469697!5469697!28057848     free     free     free       Cold+Spring+Harb+Symp+Quant+Biol 2016 ; 81 (ä): 257-67 Nephropedia Template TP {{tp|p=28057848|t=2016. A Pipeline for Drug Target Identification and Validation |pdf=|usr=}}{{28057848}} gab.com Text A Pipeline for Drug Target Identification and Validation JO: Cold Spring Harb Symp Quant Biol http://www.kidney.de/pget.php?&tw=1&pmid=28057848 #FOAvip Rapid and affordable tumor profiling has led to an explosion of genomic data that is facilitating the development of new cancer therapies. The potential of therapeutic strategies aimed at inactivating the oncogenic lesions that contribute to the aberrant survival and proliferation of tumor cells has yielded remarkable success in some malignancies such as BRAF-mutant melanoma and BCR-ABL expressing chronic myeloid leukemia. However, the direct inhibition of several well-established oncoproteins in some of these cancers is not possible or produces only transient benefits. Functional genomics represents a powerful approach for the identification of vulnerabilities linked to specific genetic alterations and has provided substantial insights into cancer signaling networks. Still, as inhibition of gene function can have diverse effects on both tumor and normal tissues, information on the potency of target inhibition on tumor growth as well as the toxic side effects of target inhibition are also needed. Here, we discuss our RNA interference (RNAi) pipeline for cancer target discovery based on our optimized short-hairpin RNA (shRNA) tools for negative selection screens and inducible RNAi platform that, in combination with embryonic stem cell (ESC)-based genetically engineered mouse models (GEMMs), enable deep in vivo target validation. Twit Text FOAVip A Pipeline for Drug Target Identification and Validation ????Cold Spring Harb Symp Quant Biol http://www.kidney.de/pget.php?&tw=1&pmid=28057848 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28057848 #FOAvip English Wikipedia <ref>{{Cite pmid|28057848}}</ref> A Pipeline for Drug Target Identification and Validation #MMPMID28057848 Manchado E; Huang CH; Tasdemir N; Tschaharganeh DF; Wilkinson JE; Lowe SW Cold Spring Harb Symp Quant Biol 2016[]; 81 (ä): 257-67 PMID28057848show ga Rapid and affordable tumor profiling has led to an explosion of genomic data that is facilitating the development of new cancer therapies. The potential of therapeutic strategies aimed at inactivating the oncogenic lesions that contribute to the aberrant survival and proliferation of tumor cells has yielded remarkable success in some malignancies such as BRAF-mutant melanoma and BCR-ABL expressing chronic myeloid leukemia. However, the direct inhibition of several well-established oncoproteins in some of these cancers is not possible or produces only transient benefits. Functional genomics represents a powerful approach for the identification of vulnerabilities linked to specific genetic alterations and has provided substantial insights into cancer signaling networks. Still, as inhibition of gene function can have diverse effects on both tumor and normal tissues, information on the potency of target inhibition on tumor growth as well as the toxic side effects of target inhibition are also needed. Here, we discuss our RNA interference (RNAi) pipeline for cancer target discovery based on our optimized short-hairpin RNA (shRNA) tools for negative selection screens and inducible RNAi platform that, in combination with embryonic stem cell (ESC)-based genetically engineered mouse models (GEMMs), enable deep in vivo target validation. äA Pipeline for Drug Target Identification and Validation (epmc).pdf DeepDyve Pubget Overpricing