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10.1042/BSR20160643 http://scihub22266oqcxt.onion/10.1042/BSR20160643 C5469333!5469333!28232512     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28232512&cmd=llinks): Failed to open stream: HTTP request failed! 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Dysregulation of Fra1 expression by Wnt/?-catenin signalling promotes glioma aggressiveness through epithelial?mesenchymal transition |pdf=|usr=}}{{28232512}} gab.com Text Dysregulation of Fra1 expression by Wnt/ -catenin signalling promotes glioma aggressiveness through epithelial mesenchymal transition JO: Biosci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28232512 #FOAvip Aberrant expression of Fos-related antigen-1 (Fra1) is commonly elevated in various malignant cancers and is strongly implicated in invasion and metastasis. However, the molecular mechanisms underlying its dysregulation in human glioma remain poorly understood. In the present study, we demonstrate that up-regulation of Fra1 plays a crucial role in the glioma aggressiveness and epithelial?mesenchymal transition (EMT) activated by Wnt/?-catenin signal pathway. In glioma cells, activation of Wnt/?-catenin signalling by Wnt3a administration obviously induced EMT and directly activated the transcription of Fra1. Phenotype experiments revealed that up-regulation of Fra1 induced by Wnt/?-catenin signalling drove the EMT of glioma cells. Furthermore, it was found that the cisplatin resistance acquired by Wnt/?-catenin signalling activation depended on increased expression of Fra1. Analysis of clinical specimens verified a positive correlation between Fra1 and ?-catenin as well as a poor prognosis in glioma patients with double-high expressions of them. These findings indicate that an aberrant Wnt/?-catenin signalling leads to the EMT and drug resistance of glioma via Fra1 induction, which suggests novel therapeutic strategies for the malignant disease. Twit Text FOAVip Dysregulation of Fra1 expression by Wnt/ -catenin signalling promotes glioma aggressiveness through epithelial mesenchymal transition ????Biosci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28232512 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28232512 #FOAvip English Wikipedia <ref>{{Cite pmid|28232512}}</ref> Dysregulation of Fra1 expression by Wnt/?-catenin signalling promotes glioma aggressiveness through epithelial?mesenchymal transition #MMPMID28232512 Zhang L; Liu H; Mu X; Cui J; Peng Z Biosci Rep 2017[Apr]; 37 (2): ä PMID28232512show ga Aberrant expression of Fos-related antigen-1 (Fra1) is commonly elevated in various malignant cancers and is strongly implicated in invasion and metastasis. However, the molecular mechanisms underlying its dysregulation in human glioma remain poorly understood. In the present study, we demonstrate that up-regulation of Fra1 plays a crucial role in the glioma aggressiveness and epithelial?mesenchymal transition (EMT) activated by Wnt/?-catenin signal pathway. In glioma cells, activation of Wnt/?-catenin signalling by Wnt3a administration obviously induced EMT and directly activated the transcription of Fra1. Phenotype experiments revealed that up-regulation of Fra1 induced by Wnt/?-catenin signalling drove the EMT of glioma cells. Furthermore, it was found that the cisplatin resistance acquired by Wnt/?-catenin signalling activation depended on increased expression of Fra1. Analysis of clinical specimens verified a positive correlation between Fra1 and ?-catenin as well as a poor prognosis in glioma patients with double-high expressions of them. These findings indicate that an aberrant Wnt/?-catenin signalling leads to the EMT and drug resistance of glioma via Fra1 induction, which suggests novel therapeutic strategies for the malignant disease. äDysregulation of Fra1 expression by Wnt/?-catenin signalling promotes (epmc).pdf DeepDyve Pubget Overpricing