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10.1073/pnas.1705499114 http://scihub22266oqcxt.onion/10.1073/pnas.1705499114 C5468617!5468617!28533362     free     free     free       Proc+Natl+Acad+Sci+U+S+A 2017 ; 114 (23): E4612-20 Nephropedia Template TP {{tp|p=28533362|t=2017. cGAS is essential for cellular senescence |pdf=|usr=}}{{28533362}} gab.com Text cGAS is essential for cellular senescence JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=28533362 #FOAvip Cellular senescence is important for the maintenance of tissue homeostasis. Dysregulation of senescence is linked to many human diseases, such as cancer, premature aging, and age-related diseases. Although DNA damage response has been linked to senescence, the underlying mechanism is unknown. Here we show that cGAS is essential for the senescence phenotypes, including expression of inflammatory genes. This finding reveals a molecular mechanism of cellular senescence and suggests that modulation of cGAS activity may be a new strategy to treat senescence-associated human diseases that potentially include cancer, neurodegenerative diseases, cardiovascular diseases, and aging. Twit Text FOAVip cGAS is essential for cellular senescence ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=28533362 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28533362 #FOAvip English Wikipedia <ref>{{Cite pmid|28533362}}</ref> cGAS is essential for cellular senescence #MMPMID28533362 Yang H; Wang H; Ren J; Chen Q; Chen ZJ Proc Natl Acad Sci U S A 2017[Jun]; 114 (23): E4612-20 PMID28533362show ga Cellular senescence is important for the maintenance of tissue homeostasis. Dysregulation of senescence is linked to many human diseases, such as cancer, premature aging, and age-related diseases. Although DNA damage response has been linked to senescence, the underlying mechanism is unknown. Here we show that cGAS is essential for the senescence phenotypes, including expression of inflammatory genes. This finding reveals a molecular mechanism of cellular senescence and suggests that modulation of cGAS activity may be a new strategy to treat senescence-associated human diseases that potentially include cancer, neurodegenerative diseases, cardiovascular diseases, and aging. äcGAS is essential for cellular senescence (epmc).pdf DeepDyve Pubget Overpricing