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10.1073/pnas.1610622114 http://scihub22266oqcxt.onion/10.1073/pnas.1610622114 C5468615!5468615!28584084     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Proc+Natl+Acad+Sci+U+S+A 2017 ; 114 (23): 5792-9 Nephropedia Template TP {{tp|p=28584084|t=2017. Logical modeling of lymphoid and myeloid cell specification and transdifferentiation |pdf=|usr=}}{{28584084}} gab.com Text Logical modeling of lymphoid and myeloid cell specification and transdifferentiation JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=28584084 #FOAvip Blood cells are derived from a common set of hematopoietic stem cells, which differentiate into more specific progenitors of the myeloid and lymphoid lineages, ultimately leading to differentiated cells. This developmental process is controlled by a complex regulatory network involving cytokines and their receptors, transcription factors, and chromatin remodelers. Using public data and data from our own molecular genetic experiments (quantitative PCR, Western blot, EMSA) or genome-wide assays (RNA-sequencing, ChIP-sequencing), we have assembled a comprehensive regulatory network encompassing the main transcription factors and signaling components involved in myeloid and lymphoid development. Focusing on B-cell and macrophage development, we defined a qualitative dynamical model recapitulating cytokine-induced differentiation of common progenitors, the effect of various reported gene knockdowns, and the reprogramming of pre-B cells into macrophages induced by the ectopic expression of specific transcription factors. The resulting network model can be used as a template for the integration of new hematopoietic differentiation and transdifferentiation data to foster our understanding of lymphoid/myeloid cell-fate decisions. Twit Text FOAVip Logical modeling of lymphoid and myeloid cell specification and transdifferentiation ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=28584084 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28584084 #FOAvip English Wikipedia <ref>{{Cite pmid|28584084}}</ref> Logical modeling of lymphoid and myeloid cell specification and transdifferentiation #MMPMID28584084 Collombet S; van Oevelen C; Sardina Ortega JL; Abou-Jaoudé W; Di Stefano B; Thomas-Chollier M; Graf T; Thieffry D Proc Natl Acad Sci U S A 2017[Jun]; 114 (23): 5792-9 PMID28584084show ga Blood cells are derived from a common set of hematopoietic stem cells, which differentiate into more specific progenitors of the myeloid and lymphoid lineages, ultimately leading to differentiated cells. This developmental process is controlled by a complex regulatory network involving cytokines and their receptors, transcription factors, and chromatin remodelers. Using public data and data from our own molecular genetic experiments (quantitative PCR, Western blot, EMSA) or genome-wide assays (RNA-sequencing, ChIP-sequencing), we have assembled a comprehensive regulatory network encompassing the main transcription factors and signaling components involved in myeloid and lymphoid development. Focusing on B-cell and macrophage development, we defined a qualitative dynamical model recapitulating cytokine-induced differentiation of common progenitors, the effect of various reported gene knockdowns, and the reprogramming of pre-B cells into macrophages induced by the ectopic expression of specific transcription factors. The resulting network model can be used as a template for the integration of new hematopoietic differentiation and transdifferentiation data to foster our understanding of lymphoid/myeloid cell-fate decisions. äLogical modeling of lymphoid and myeloid cell specification and transd(epmc).pdf DeepDyve Pubget Overpricing