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10.1073/pnas.1703057114 http://scihub22266oqcxt.onion/10.1073/pnas.1703057114 C5468602!5468602!28533359     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Proc+Natl+Acad+Sci+U+S+A 2017 ; 114 (23): E4574-81 Nephropedia Template TP {{tp|p=28533359|t=2017. Selective regulation of Notch ligands during angiogenesis is mediated by vimentin |pdf=|usr=}}{{28533359}} gab.com Text Selective regulation of Notch ligands during angiogenesis is mediated by vimentin JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=28533359 #FOAvip Angiogenesis, the formation of new blood vessels from existing ones, is essential for embryonic development and necessary for tumor growth and invasion. The Notch signaling pathway regulates angiogenesis where the two Notch ligands, Dll4 and Jagged 1, exert opposite functions on sprouting. We found that the intermediate filament vimentin balances angiogenesis by binding specifically to the proangiogenic Jagged ligands. This binding provides a force-generating mechanism on the Jagged?Notch complex to ensure efficient transendocytosis and Notch activation. The interaction between vimentin and Jagged constitutes a mechanism behind selective regulation of Notch ligands during angiogenesis. The interaction may be amendable by therapeutic intervention and can facilitate strategies targeting a variety of diseases related to Jagged deregulation. Twit Text FOAVip Selective regulation of Notch ligands during angiogenesis is mediated by vimentin ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=28533359 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28533359 #FOAvip English Wikipedia <ref>{{Cite pmid|28533359}}</ref> Selective regulation of Notch ligands during angiogenesis is mediated by vimentin #MMPMID28533359 Antfolk D; Sjöqvist M; Cheng F; Isoniemi K; Duran CL; Rivero-Muller A; Antila C; Niemi R; Landor S; Bouten CVC; Bayless KJ; Eriksson JE; Sahlgren CM Proc Natl Acad Sci U S A 2017[Jun]; 114 (23): E4574-81 PMID28533359show ga Angiogenesis, the formation of new blood vessels from existing ones, is essential for embryonic development and necessary for tumor growth and invasion. The Notch signaling pathway regulates angiogenesis where the two Notch ligands, Dll4 and Jagged 1, exert opposite functions on sprouting. We found that the intermediate filament vimentin balances angiogenesis by binding specifically to the proangiogenic Jagged ligands. This binding provides a force-generating mechanism on the Jagged?Notch complex to ensure efficient transendocytosis and Notch activation. The interaction between vimentin and Jagged constitutes a mechanism behind selective regulation of Notch ligands during angiogenesis. The interaction may be amendable by therapeutic intervention and can facilitate strategies targeting a variety of diseases related to Jagged deregulation. äSelective regulation of Notch ligands during angiogenesis is mediated (epmc).pdf DeepDyve Pubget Overpricing