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10.1155/2017/2647129 http://scihub22266oqcxt.onion/10.1155/2017/2647129 C5468594!5468594!28638404     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       PPAR+Res 2017 ; 2017 (ä): ä Nephropedia Template TP {{tp|p=28638404|t=2017. Puerarin Protects against Cardiac Fibrosis Associated with the Inhibition of TGF-?1/Smad2-Mediated Endothelial-to-Mesenchymal Transition |pdf=|usr=}}{{28638404}} gab.com Text Puerarin Protects against Cardiac Fibrosis Associated with the Inhibition of TGF- 1/Smad2-Mediated Endothelial-to-Mesenchymal Transition JO: PPAR Res http://www.kidney.de/pget.php?&tw=1&pmid=28638404 #FOAvip Background: Puerarin is a kind of flavonoids and is extracted from Chinese herb Kudzu root. Puerarin is widely used as an adjuvant therapy in Chinese clinics. But little is known about its effects on regulating cardiac fibrosis. Methods: Mice were subjected to transverse aorta constriction (TAC) for 8 weeks; meanwhile puerarin was given 1 week after TAC. Cardiac fibrosis was assessed by pathological staining. The mRNA and protein changes of CD31 and vimentin in both animal and human umbilical vein endothelial cells (HUVECs) models were detected. Immunofluorescence colocalization of CD31 and vimentin and scratch test were carried out to examine TGF-?1-induced changes in HUVECs. The agonist and antagonist of peroxisome proliferator-activated receptor-? (PPAR-?) were used to explore the underlying mechanism. Results: Puerarin mitigated TAC-induced cardiac fibrosis, accompanied with suppressed endothelial-to-mesenchymal transition (EndMT). The consistent results were achieved in HUVECs model. TGF-?1/Smad2 signaling pathway was blunted and PPAR-? expression was upregulated in puerarin-treated mice and HUVECs. Pioglitazone could reproduce the protective effect in HUVECs, while GW9662 reversed this effect imposed by puerarin. Conclusion: Puerarin protected against TAC-induced cardiac fibrosis, and this protective effect may be attributed to the upregulation of PPAR-? and the inhibition of TGF-?1/Smad2-mediated EndMT. Twit Text FOAVip Puerarin Protects against Cardiac Fibrosis Associated with the Inhibition of TGF- 1/Smad2-Mediated Endothelial-to-Mesenchymal Transition ????PPAR Res http://www.kidney.de/pget.php?&tw=1&pmid=28638404 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28638404 #FOAvip English Wikipedia <ref>{{Cite pmid|28638404}}</ref> Puerarin Protects against Cardiac Fibrosis Associated with the Inhibition of TGF-?1/Smad2-Mediated Endothelial-to-Mesenchymal Transition #MMPMID28638404 Jin YG; Yuan Y; Wu QQ; Zhang N; Fan D; Che Y; Wang ZP; Xiao Y; Wang SS; Tang QZ PPAR Res 2017[]; 2017 (ä): ä PMID28638404show ga Background: Puerarin is a kind of flavonoids and is extracted from Chinese herb Kudzu root. Puerarin is widely used as an adjuvant therapy in Chinese clinics. But little is known about its effects on regulating cardiac fibrosis. Methods: Mice were subjected to transverse aorta constriction (TAC) for 8 weeks; meanwhile puerarin was given 1 week after TAC. Cardiac fibrosis was assessed by pathological staining. The mRNA and protein changes of CD31 and vimentin in both animal and human umbilical vein endothelial cells (HUVECs) models were detected. Immunofluorescence colocalization of CD31 and vimentin and scratch test were carried out to examine TGF-?1-induced changes in HUVECs. The agonist and antagonist of peroxisome proliferator-activated receptor-? (PPAR-?) were used to explore the underlying mechanism. Results: Puerarin mitigated TAC-induced cardiac fibrosis, accompanied with suppressed endothelial-to-mesenchymal transition (EndMT). The consistent results were achieved in HUVECs model. TGF-?1/Smad2 signaling pathway was blunted and PPAR-? expression was upregulated in puerarin-treated mice and HUVECs. Pioglitazone could reproduce the protective effect in HUVECs, while GW9662 reversed this effect imposed by puerarin. Conclusion: Puerarin protected against TAC-induced cardiac fibrosis, and this protective effect may be attributed to the upregulation of PPAR-? and the inhibition of TGF-?1/Smad2-mediated EndMT. äPuerarin Protects against Cardiac Fibrosis Associated with the Inhibit(epmc).pdf DeepDyve Pubget Overpricing