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10.1111/aji.12669 http://scihub22266oqcxt.onion/10.1111/aji.12669 C5468471!5468471!28337819     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Am+J+Reprod+Immunol 2017 ; 78 (1): ä Nephropedia Template TP {{tp|p=28337819|t=2017. PAI-1 in granulosa cells is suppressed directly by statin and indirectly by suppressing TGF-? and TNF-? in mononuclear cells by insulin sensitizing drugs |pdf=|usr=}}{{28337819}} gab.com Text PAI-1 in granulosa cells is suppressed directly by statin and indirectly by suppressing TGF- and TNF- in mononuclear cells by insulin sensitizing drugs JO: Am J Reprod Immunol http://www.kidney.de/pget.php?&tw=1&pmid=28337819 #FOAvip Problem: Plasminogen activator inhibitor-1 (PAI-1) is elevated in women with polycystic ovary syndrome (PCOS), but the regulation in granulosa cells (GCs) is unclear. Method of Study: PAI-1 expression in PCOS ovaries were investigated immunohistologically. PAI-1 expressions in HGrC1, a human GC cell line, were investigated at mRNA and activity levels. The expressions of TGF-? and TNF-? in peritoneal fluid mononuclear cells (PFMC) were measured with quantitative PCR. Results: Little PAI-1 expression is observed in healthy GCs whereas GCs of PCOS and atretic follicle exhibit distinct expression in vivo. In vitro study using HGrC1 shows that TGF-? and TNF-? increase PAI-1 mRNA and its activity, and both together exhibit a synergistic effect. The expression of PAI-1 mRNA is suppressed by simvastatin. Moreover, insulin sensitizing drugs (metformin, pioglitazone and rosiglitazone) suppress LPS-induced TGF-? and TNF-? mRNA expression in PFMC. Conclusions: Statin and insulin sensitizing drugs may provide a potential therapy for PCOS via down-regulation of PAI-1 expression in GCs and down-regulation of TGF-? and TNF-? expression in PFMC, respectively. Twit Text FOAVip PAI-1 in granulosa cells is suppressed directly by statin and indirectly by suppressing TGF- and TNF- in mononuclear cells by insulin sensitizing drugs ????Am J Reprod Immunol http://www.kidney.de/pget.php?&tw=1&pmid=28337819 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28337819 #FOAvip English Wikipedia <ref>{{Cite pmid|28337819}}</ref> PAI-1 in granulosa cells is suppressed directly by statin and indirectly by suppressing TGF-? and TNF-? in mononuclear cells by insulin sensitizing drugs #MMPMID28337819 Yamada-Nomoto K; Yoshino O; Akiyama I; Iwase A; Yosuke O; Nakamura T; Harada M; Nakashima A; Shima T; Ushijima A; Osuga Y; Chang RJ; Shimasaki S; Saito S Am J Reprod Immunol 2017[Jul]; 78 (1): ä PMID28337819show ga Problem: Plasminogen activator inhibitor-1 (PAI-1) is elevated in women with polycystic ovary syndrome (PCOS), but the regulation in granulosa cells (GCs) is unclear. Method of Study: PAI-1 expression in PCOS ovaries were investigated immunohistologically. PAI-1 expressions in HGrC1, a human GC cell line, were investigated at mRNA and activity levels. The expressions of TGF-? and TNF-? in peritoneal fluid mononuclear cells (PFMC) were measured with quantitative PCR. Results: Little PAI-1 expression is observed in healthy GCs whereas GCs of PCOS and atretic follicle exhibit distinct expression in vivo. In vitro study using HGrC1 shows that TGF-? and TNF-? increase PAI-1 mRNA and its activity, and both together exhibit a synergistic effect. The expression of PAI-1 mRNA is suppressed by simvastatin. Moreover, insulin sensitizing drugs (metformin, pioglitazone and rosiglitazone) suppress LPS-induced TGF-? and TNF-? mRNA expression in PFMC. Conclusions: Statin and insulin sensitizing drugs may provide a potential therapy for PCOS via down-regulation of PAI-1 expression in GCs and down-regulation of TGF-? and TNF-? expression in PFMC, respectively. äPAI-1 in granulosa cells is suppressed directly by statin and indirect(epmc).pdf DeepDyve Pubget Overpricing