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10.1111/aji.12669 http://scihub22266oqcxt.onion/10.1111/aji.12669 C5468471!5468471 !28337819     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28337819 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Am+J+Reprod+Immunol 2017 ; 78 (1 ): ä Nephropedia Template TP {{tp|p=28337819 |t=2017. PAI-1 in granulosa cells is suppressed directly by statin and indirectly by suppressing TGF-? and TNF-? in mononuclear cells by insulin-sensitizing drugs |pdf=|usr=}}{{28337819 }} gab.com Text PAI-1 in granulosa cells is suppressed directly by statin and indirectly by suppressing TGF- and TNF- in mononuclear cells by insulin-sensitizing drugs JO: Am J Reprod Immunol http://www.kidney.de/pget.php?&tw=1&pmid=28337819 #FOAvip PROBLEM: Plasminogen activator inhibitor-1 (PAI-1) is elevated in women with polycystic ovary syndrome (PCOS), but the regulation in granulosa cells (GCs) is unclear. METHOD OF STUDY: PAI-1 expression in PCOS ovaries was investigated immunohistologically. PAI-1 expressions in HGrC1, a human GC cell line, were investigated at mRNA and activity levels. The expressions of TGF-? and TNF-? in peritoneal fluid mononuclear cells (PFMCs) were measured with quantitative PCR. RESULTS: Little PAI-1 expression is observed in healthy GCs, whereas GCs of PCOS and atretic follicle exhibit distinct expression in vivo. In vitro study using HGrC1 shows that TGF-? and TNF-? increase PAI-1 mRNA and its activity, and both together exhibit a synergistic effect. The expression of PAI-1 mRNA is suppressed by simvastatin. Moreover, insulin-sensitizing drugs (metformin, pioglitazone, and rosiglitazone) suppress LPS-induced TGF-? and TNF-? mRNA expression in PFMC. CONCLUSION: Statin and insulin-sensitizing drugs may provide a potential therapy for PCOS via down-regulation of PAI-1 expression in GCs and down-regulation of TGF-? and TNF-? expression in PFMC, respectively. Twit Text FOAVip PAI-1 in granulosa cells is suppressed directly by statin and indirectly by suppressing TGF- and TNF- in mononuclear cells by insulin-sensitizing drugs ????Am J Reprod Immunol http://www.kidney.de/pget.php?&tw=1&pmid=28337819 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28337819 #FOAvip English Wikipedia <ref>{{Cite pmid|28337819 }}</ref> PAI-1 in granulosa cells is suppressed directly by statin and indirectly by suppressing TGF-? and TNF-? in mononuclear cells by insulin-sensitizing drugs #MMPMID28337819 Yamada-Nomoto K ; Yoshino O ; Akiyama I ; Iwase A ; Ono Y ; Nakamura T ; Harada M ; Nakashima A ; Shima T ; Ushijima A ; Osuga Y ; Chang RJ ; Shimasaki S ; Saito S Am J Reprod Immunol 2017[Jul]; 78 (1 ): ä PMID28337819 show ga PROBLEM: Plasminogen activator inhibitor-1 (PAI-1) is elevated in women with polycystic ovary syndrome (PCOS), but the regulation in granulosa cells (GCs) is unclear. METHOD OF STUDY: PAI-1 expression in PCOS ovaries was investigated immunohistologically. PAI-1 expressions in HGrC1, a human GC cell line, were investigated at mRNA and activity levels. The expressions of TGF-? and TNF-? in peritoneal fluid mononuclear cells (PFMCs) were measured with quantitative PCR. RESULTS: Little PAI-1 expression is observed in healthy GCs, whereas GCs of PCOS and atretic follicle exhibit distinct expression in vivo. In vitro study using HGrC1 shows that TGF-? and TNF-? increase PAI-1 mRNA and its activity, and both together exhibit a synergistic effect. The expression of PAI-1 mRNA is suppressed by simvastatin. Moreover, insulin-sensitizing drugs (metformin, pioglitazone, and rosiglitazone) suppress LPS-induced TGF-? and TNF-? mRNA expression in PFMC. CONCLUSION: Statin and insulin-sensitizing drugs may provide a potential therapy for PCOS via down-regulation of PAI-1 expression in GCs and down-regulation of TGF-? and TNF-? expression in PFMC, respectively. |Ascitic Fluid/cytology [MESH] |Cell Line [MESH] |Female [MESH] |Granulosa Cells/*drug effects/metabolism [MESH] |Humans [MESH] |Hydroxymethylglutaryl-CoA Reductase Inhibitors/*pharmacology [MESH] |Hypoglycemic Agents/*pharmacology [MESH] |Leukocytes, Mononuclear/*drug effects/metabolism [MESH] |Lipopolysaccharides [MESH] |Ovarian Follicle/metabolism [MESH] |Plasminogen Activator Inhibitor 1/genetics/*metabolism [MESH] |Polycystic Ovary Syndrome/metabolism [MESH] |Protein Kinase Inhibitors/pharmacology [MESH] |RNA, Messenger/metabolism [MESH] |Simvastatin/pharmacology [MESH] |Transforming Growth Factor beta/*genetics [MESH]PAI-1 in granulosa cells is suppressed directly by statin and indirect(epmc).pdf DeepDyve Pubget Overpricing