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10.1038/s41598-017-03740-7 http://scihub22266oqcxt.onion/10.1038/s41598-017-03740-7 C5468253!5468253 !28607410     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28607410 &cmd=llinks): Failed to open stream: HTTP request failed! 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DC-SIGN and Toll-like receptor 4 mediate oxidized low-density lipoprotein-induced inflammatory responses in macrophages |pdf=|usr=}}{{28607410 }} gab.com Text DC-SIGN and Toll-like receptor 4 mediate oxidized low-density lipoprotein-induced inflammatory responses in macrophages JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28607410 #FOAvip The regulation of inflammatory responses by innate immune receptors is recognized as a crucial step in the development of atherosclerosis, although the precise molecular mechanisms remain to be elucidated. This study focused on illustrating the roles of dendritic cell-specific intercellular adhesion molecule-3-grabbing non-integrin (DC-SIGN)- and Toll-like receptor 4 (TLR4)-regulated inflammatory responses in macrophages. We found that DC-SIGN expression levels were increased in macrophages of atherosclerotic plaques. Oxidized low-density lipoprotein (oxLDL) significantly enhanced DC-SIGN protein expression levels after a short-term exposure. Knockdown of DC-SIGN decreased expression and secretion of interleukin 1-? (IL1-?), monocyte chemo-attractant protein 1 (MCP-1), tumor necrosis factor-? (TNF?) and matrix metalloproteinase-9 (MMP-9). Immunofluorescence studies demonstrated that DC-SIGN and TLR4 co-localized in regions of the plaques. Moreover, DC-SIGN was co-expressed with TLR4 on the plasma membrane after oxLDL stimulation. The presence of an endogenous interaction and the results of the in vitro pull-down assays revealed that DC-SIGN binds directly with TLR4. We also present evidence that DC-SIGN mediates TLR4-regulated NF?B activation but not activation of p38 and JNK. Our results suggest an essential role of DC-SIGN/TLR4 signaling in macrophages in the pathogenesis of atherosclerosis. Twit Text FOAVip DC-SIGN and Toll-like receptor 4 mediate oxidized low-density lipoprotein-induced inflammatory responses in macrophages ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28607410 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28607410 #FOAvip English Wikipedia <ref>{{Cite pmid|28607410 }}</ref> DC-SIGN and Toll-like receptor 4 mediate oxidized low-density lipoprotein-induced inflammatory responses in macrophages #MMPMID28607410 Yang K ; Liu X ; Liu Y ; Wang X ; Cao L ; Zhang X ; Xu C ; Shen W ; Zhou T Sci Rep 2017[Jun]; 7 (1 ): 3296 PMID28607410 show ga The regulation of inflammatory responses by innate immune receptors is recognized as a crucial step in the development of atherosclerosis, although the precise molecular mechanisms remain to be elucidated. This study focused on illustrating the roles of dendritic cell-specific intercellular adhesion molecule-3-grabbing non-integrin (DC-SIGN)- and Toll-like receptor 4 (TLR4)-regulated inflammatory responses in macrophages. We found that DC-SIGN expression levels were increased in macrophages of atherosclerotic plaques. Oxidized low-density lipoprotein (oxLDL) significantly enhanced DC-SIGN protein expression levels after a short-term exposure. Knockdown of DC-SIGN decreased expression and secretion of interleukin 1-? (IL1-?), monocyte chemo-attractant protein 1 (MCP-1), tumor necrosis factor-? (TNF?) and matrix metalloproteinase-9 (MMP-9). Immunofluorescence studies demonstrated that DC-SIGN and TLR4 co-localized in regions of the plaques. Moreover, DC-SIGN was co-expressed with TLR4 on the plasma membrane after oxLDL stimulation. The presence of an endogenous interaction and the results of the in vitro pull-down assays revealed that DC-SIGN binds directly with TLR4. We also present evidence that DC-SIGN mediates TLR4-regulated NF?B activation but not activation of p38 and JNK. Our results suggest an essential role of DC-SIGN/TLR4 signaling in macrophages in the pathogenesis of atherosclerosis. |Atherosclerosis/metabolism/pathology [MESH] |Cell Adhesion Molecules/*metabolism [MESH] |Cytokines/metabolism [MESH] |Female [MESH] |Gene Knockdown Techniques [MESH] |HEK293 Cells [MESH] |Humans [MESH] |Inflammation Mediators/metabolism [MESH] |Inflammation/*pathology [MESH] |Lectins, C-Type/*metabolism [MESH] |Lipoproteins, LDL/*metabolism [MESH] |Macrophages/*metabolism/*pathology [MESH] |Male [MESH] |Middle Aged [MESH] |Plaque, Atherosclerotic/pathology [MESH] |Protein Binding [MESH] |Receptors, Cell Surface/*metabolism [MESH] |Toll-Like Receptor 4/*metabolism [MESH]DC-SIGN and Toll-like receptor 4 mediate oxidized low-density lipoprot(epmc).pdf DeepDyve Pubget Overpricing