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10.1038/s41598-017-03474-6 http://scihub22266oqcxt.onion/10.1038/s41598-017-03474-6 C5468249!5468249 !28607392     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28607392 &cmd=llinks): Failed to open stream: HTTP request failed! 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Chronic vitamin D deficiency induces lung fibrosis through activation of the renin-angiotensin system |pdf=|usr=}}{{28607392 }} gab.com Text Chronic vitamin D deficiency induces lung fibrosis through activation of the renin-angiotensin system JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28607392 #FOAvip Pulmonary fibrosis, which influences lung function and exacerbates a patient's condition, is the ultimate stage of many lung diseases. Vitamin D deficiency is associated with pulmonary fibrosis and impaired lung function, but the underlying mechanism has not yet been fully elucidated. Moreover, vitamin D deficiency may cause over-activation of the renin-angiotensin system (RAS), which aggravates extracellular matrix (ECM) deposition and lung fibrosis. This study aims to investigate the effect of chronic vitamin D deficiency on lung fibrosis in otherwise healthy mice and to explore the role of RAS in this process. Mice were depleted of vitamin D through diet control and were compared with healthy subjects. Chronic vitamin D deficiency destructs lung structures, impairs lung development and stimulates ECM deposition. RAS components are also found to increase. These effects seem to worsen with prolonged vitamin D deficiency. By giving RAS blockers, these changes can be largely rescued. However, a smooth muscle relaxant whose regulatory effect on blood pressure is independent of RAS does not show similar effects. This study demonstrated that chronic vitamin D deficiency may induce RAS activation, which subsequently stimulates the expression of profibrotic factors and activates the fibrotic cascade. This profibrotic effect of RAS is independent of elevated blood pressure. Twit Text FOAVip Chronic vitamin D deficiency induces lung fibrosis through activation of the renin-angiotensin system ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28607392 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28607392 #FOAvip English Wikipedia <ref>{{Cite pmid|28607392 }}</ref> Chronic vitamin D deficiency induces lung fibrosis through activation of the renin-angiotensin system #MMPMID28607392 Shi Y ; Liu T ; Yao L ; Xing Y ; Zhao X ; Fu J ; Xue X Sci Rep 2017[Jun]; 7 (1 ): 3312 PMID28607392 show ga Pulmonary fibrosis, which influences lung function and exacerbates a patient's condition, is the ultimate stage of many lung diseases. Vitamin D deficiency is associated with pulmonary fibrosis and impaired lung function, but the underlying mechanism has not yet been fully elucidated. Moreover, vitamin D deficiency may cause over-activation of the renin-angiotensin system (RAS), which aggravates extracellular matrix (ECM) deposition and lung fibrosis. This study aims to investigate the effect of chronic vitamin D deficiency on lung fibrosis in otherwise healthy mice and to explore the role of RAS in this process. Mice were depleted of vitamin D through diet control and were compared with healthy subjects. Chronic vitamin D deficiency destructs lung structures, impairs lung development and stimulates ECM deposition. RAS components are also found to increase. These effects seem to worsen with prolonged vitamin D deficiency. By giving RAS blockers, these changes can be largely rescued. However, a smooth muscle relaxant whose regulatory effect on blood pressure is independent of RAS does not show similar effects. This study demonstrated that chronic vitamin D deficiency may induce RAS activation, which subsequently stimulates the expression of profibrotic factors and activates the fibrotic cascade. This profibrotic effect of RAS is independent of elevated blood pressure. |*Renin-Angiotensin System/drug effects [MESH] |Amides/pharmacology/therapeutic use [MESH] |Animals [MESH] |Blood Pressure/drug effects [MESH] |Chronic Disease [MESH] |Extracellular Matrix/drug effects/metabolism [MESH] |Female [MESH] |Fumarates/pharmacology/therapeutic use [MESH] |Losartan/pharmacology/therapeutic use [MESH] |Lung/metabolism/pathology [MESH] |Mice [MESH] |Pulmonary Fibrosis/drug therapy/*etiology/*metabolism/physiopathology [MESH]Chronic vitamin D deficiency induces lung fibrosis through activation (epmc).pdf DeepDyve Pubget Overpricing