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10.1016/j.celrep.2017.03.066 http://scihub22266oqcxt.onion/10.1016/j.celrep.2017.03.066 C5468096!5468096!28423312     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Rep 2017 ; 19 (3): 479-86 Nephropedia Template TP {{tp|p=28423312|t=2017. HGFA is an injury-regulated systemic factor that induces the transition of stem cells into GAlert |pdf=|usr=}}{{28423312}} gab.com Text HGFA is an injury-regulated systemic factor that induces the transition of stem cells into GAlert JO: Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=28423312 #FOAvip The activation of quiescent stem cells into the cell cycle is a key step in initiating the process of tissue repair. We recently reported that quiescent stem cells can transition into GAlert, a cellular state in which they have an increased functional ability to activate and participate in tissue repair. However, the precise molecular signals which induce GAlert in stem cells have remained elusive. Here, we show that the injury-induced regulation of Hepatocyte Growth Factor (HGF) proteolytic processing via the systemic protease, Hepatocyte Growth Factor Activator (HGFA), stimulates GAlert in skeletal muscle stem cells (MuSCs) and fibro-adipogenic progenitors (FAPs). We demonstrate that administering active HGFA to animals is sufficient to induce GAlert in stem cells throughout the body and to significantly accelerate the processes of stem cell activation and tissue repair. Our data suggest that factors that induce GAlert will have broad therapeutic applications for regenerative medicine and wound healing. Twit Text FOAVip HGFA is an injury-regulated systemic factor that induces the transition of stem cells into GAlert ????Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=28423312 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28423312 #FOAvip English Wikipedia <ref>{{Cite pmid|28423312}}</ref> HGFA is an injury-regulated systemic factor that induces the transition of stem cells into GAlert #MMPMID28423312 Rodgers JT; Schroeder MD; Ma C; Rando TA Cell Rep 2017[Apr]; 19 (3): 479-86 PMID28423312show ga The activation of quiescent stem cells into the cell cycle is a key step in initiating the process of tissue repair. We recently reported that quiescent stem cells can transition into GAlert, a cellular state in which they have an increased functional ability to activate and participate in tissue repair. However, the precise molecular signals which induce GAlert in stem cells have remained elusive. Here, we show that the injury-induced regulation of Hepatocyte Growth Factor (HGF) proteolytic processing via the systemic protease, Hepatocyte Growth Factor Activator (HGFA), stimulates GAlert in skeletal muscle stem cells (MuSCs) and fibro-adipogenic progenitors (FAPs). We demonstrate that administering active HGFA to animals is sufficient to induce GAlert in stem cells throughout the body and to significantly accelerate the processes of stem cell activation and tissue repair. Our data suggest that factors that induce GAlert will have broad therapeutic applications for regenerative medicine and wound healing. äHGFA is an injury-regulated systemic factor that induces the transitio(epmc).pdf DeepDyve Pubget Overpricing