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10.1080/2162402X.2017.1313369 http://scihub22266oqcxt.onion/10.1080/2162402X.2017.1313369 C5467993!5467993!28638741     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Oncoimmunology 2017 ; 6 (5): ä Nephropedia Template TP {{tp|p=28638741|t=2017. Innate ??T17 cells play a protective role in DSS-induced colitis via recruitment of Gr-1+CD11b+ myeloid suppressor cells |pdf=|usr=}}{{28638741}} gab.com Text Innate T17 cells play a protective role in DSS-induced colitis via recruitment of Gr-1+CD11b+ myeloid suppressor cells JO: Oncoimmunology http://www.kidney.de/pget.php?&tw=1&pmid=28638741 #FOAvip Innate ?? T cells play critical roles in mucosal immunity such as regulating intestinal epithelial homeostasis. In addition, ?? T cells are significantly increased in the inflamed mucosa of patients with ulcerative colitis. However, ?? T cells are a heterogeneous population. IL-17-producing versus IFN?-producing ?? T cells play differential roles in different disease settings. Therefore, dissecting the exact role of different subsets of ?? T cells in colitis is essential for understanding colitis immunopathogenesis. In the current study, we found that TCR ?-deficient mice had a more severe dextran sodium sulfate (DSS)-induced colitis that was reduced upon reconstitution of ??T17 cells but not IFN?-producing ?? T cells. Immunophenotyping of the cellular infiltrate upon DSS-induced colitis showed a reduced infiltration of Gr-1+CD11b+ myeloid cells into the sites of inflammation in mice lacking ??T17 cells. Further experiments demonstrated that IL-17, IL-18, and chemokine CXCL5 were critical in Gr-1+CD11b+ myeloid cell recruitment. In vitro T cell suppressive assay indicated that this Gr-1+CD11b+ population was immunosuppressive. Depletion of Gr-1+CD11b+ myeloid cells resulted in an increase severity of DSS-induced colitis. Our study elucidates a new immune pathway involving ??T17-dependent recruitment of Gr-1+CD11b+ myeloid cells to the site of colitis inflammation important in the protection of colitis initiation and progression. Twit Text FOAVip Innate T17 cells play a protective role in DSS-induced colitis via recruitment of Gr-1+CD11b+ myeloid suppressor cells ????Oncoimmunology http://www.kidney.de/pget.php?&tw=1&pmid=28638741 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28638741 #FOAvip English Wikipedia <ref>{{Cite pmid|28638741}}</ref> Innate ??T17 cells play a protective role in DSS-induced colitis via recruitment of Gr-1+CD11b+ myeloid suppressor cells #MMPMID28638741 Sun X; Cai Y; Fleming C; Tong Z; Wang Z; Ding C; Qu M; Zhang Hg; Suo J; Yan J Oncoimmunology 2017[]; 6 (5): ä PMID28638741show ga Innate ?? T cells play critical roles in mucosal immunity such as regulating intestinal epithelial homeostasis. In addition, ?? T cells are significantly increased in the inflamed mucosa of patients with ulcerative colitis. However, ?? T cells are a heterogeneous population. IL-17-producing versus IFN?-producing ?? T cells play differential roles in different disease settings. Therefore, dissecting the exact role of different subsets of ?? T cells in colitis is essential for understanding colitis immunopathogenesis. In the current study, we found that TCR ?-deficient mice had a more severe dextran sodium sulfate (DSS)-induced colitis that was reduced upon reconstitution of ??T17 cells but not IFN?-producing ?? T cells. Immunophenotyping of the cellular infiltrate upon DSS-induced colitis showed a reduced infiltration of Gr-1+CD11b+ myeloid cells into the sites of inflammation in mice lacking ??T17 cells. Further experiments demonstrated that IL-17, IL-18, and chemokine CXCL5 were critical in Gr-1+CD11b+ myeloid cell recruitment. In vitro T cell suppressive assay indicated that this Gr-1+CD11b+ population was immunosuppressive. Depletion of Gr-1+CD11b+ myeloid cells resulted in an increase severity of DSS-induced colitis. Our study elucidates a new immune pathway involving ??T17-dependent recruitment of Gr-1+CD11b+ myeloid cells to the site of colitis inflammation important in the protection of colitis initiation and progression. äInnate ??T17 cells play a protective role in DSS-induced colitis via r(epmc).pdf DeepDyve Pubget Overpricing