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10.1177/2045893217701438 http://scihub22266oqcxt.onion/10.1177/2045893217701438 C5467931!5467931!28597757     free     free     free       Pulm+Circ 2017 ; 7 (2): 285-99 Nephropedia Template TP {{tp|p=28597757|t=2017. The cancer theory of pulmonary arterial hypertension |pdf=|usr=}}{{28597757}} gab.com Text The cancer theory of pulmonary arterial hypertension JO: Pulm Circ http://www.kidney.de/pget.php?&tw=1&pmid=28597757 #FOAvip Pulmonary arterial hypertension (PAH) remains a mysterious killer that, like cancer, is characterized by tremendous complexity. PAH development occurs under sustained and persistent environmental stress, such as inflammation, shear stress, pseudo-hypoxia, and more. After inducing an initial death of the endothelial cells, these environmental stresses contribute with time to the development of hyper-proliferative and apoptotic resistant clone of cells including pulmonary artery smooth muscle cells, fibroblasts, and even pulmonary artery endothelial cells allowing vascular remodeling and PAH development. Molecularly, these cells exhibit many features common to cancer cells offering the opportunity to exploit therapeutic strategies used in cancer to treat PAH. In this review, we outline the signaling pathways and mechanisms described in cancer that drive PAH cells? survival and proliferation and discuss the therapeutic potential of antineoplastic drugs in PAH. Twit Text FOAVip The cancer theory of pulmonary arterial hypertension ????Pulm Circ http://www.kidney.de/pget.php?&tw=1&pmid=28597757 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28597757 #FOAvip English Wikipedia <ref>{{Cite pmid|28597757}}</ref> The cancer theory of pulmonary arterial hypertension #MMPMID28597757 Boucherat O; Vitry G; Trinh I; Paulin R; Provencher S; Bonnet S Pulm Circ 2017[Jun]; 7 (2): 285-99 PMID28597757show ga Pulmonary arterial hypertension (PAH) remains a mysterious killer that, like cancer, is characterized by tremendous complexity. PAH development occurs under sustained and persistent environmental stress, such as inflammation, shear stress, pseudo-hypoxia, and more. After inducing an initial death of the endothelial cells, these environmental stresses contribute with time to the development of hyper-proliferative and apoptotic resistant clone of cells including pulmonary artery smooth muscle cells, fibroblasts, and even pulmonary artery endothelial cells allowing vascular remodeling and PAH development. Molecularly, these cells exhibit many features common to cancer cells offering the opportunity to exploit therapeutic strategies used in cancer to treat PAH. In this review, we outline the signaling pathways and mechanisms described in cancer that drive PAH cells? survival and proliferation and discuss the therapeutic potential of antineoplastic drugs in PAH. äThe cancer theory of pulmonary arterial hypertension (epmc).pdf DeepDyve Pubget Overpricing