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10.3892/ijo.2017.4009 http://scihub22266oqcxt.onion/10.3892/ijo.2017.4009 C5467786!5467786 !28534933     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28534933 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Int+J+Oncol 2017 ; 51 (1 ): 115-127 Nephropedia Template TP {{tp|p=28534933 |t=2017. CUEDC2 suppresses glioma tumorigenicity by inhibiting the activation of STAT3 and NF-?B signaling pathway |pdf=|usr=}}{{28534933 }} gab.com Text CUEDC2 suppresses glioma tumorigenicity by inhibiting the activation of STAT3 and NF- B signaling pathway JO: Int J Oncol http://www.kidney.de/pget.php?&tw=1&pmid=28534933 #FOAvip CUEDC2, a CUE domain containing 2 protein, plays critical roles in many biological processes, such as cell cycle, inflammation and tumorigenesis. However, whether CUEDC2 was involved in tumorigenesis of glioma and the possible mechanism remains to be elucidated. In the present study, our results implied that the expression of CUEDC2 was lower in the glioma tissue and glioma cell lines than that of normal tissue and asctrocyte cells. Downregulation of endogenous CUEDC2 in glioma U251 cell lines by RNAi promoted the tumor cells proliferation, migration, invasion and glioma neurosphere formation, while, overexpression of CUEDC2 showed the opposite effect. Further studies showed that overexpression of CUEDC2 suppressed the activation and nuclear translocation of phosphorylated-STAT3 (p-STAT3) but the level of p-STAT3 increased after interfering with the expression of CUEDC2. Moreover, CUEDC2 expression has an inhibitory effect on the activation of NF-?B. Thus, our studies suggested that the decreased expression of CUEDC2 in glioma led to the activation of transcription factor STAT3 and NF-?B signaling pathway which may be related to the tumorigenicity in glioma. Twit Text FOAVip CUEDC2 suppresses glioma tumorigenicity by inhibiting the activation of STAT3 and NF- B signaling pathway ????Int J Oncol http://www.kidney.de/pget.php?&tw=1&pmid=28534933 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28534933 #FOAvip English Wikipedia <ref>{{Cite pmid|28534933 }}</ref> CUEDC2 suppresses glioma tumorigenicity by inhibiting the activation of STAT3 and NF-?B signaling pathway #MMPMID28534933 Li F ; Tang C ; Jin D ; Guan L ; Wu Y ; Liu X ; Wu X ; Wu QY ; Gao D Int J Oncol 2017[Jul]; 51 (1 ): 115-127 PMID28534933 show ga CUEDC2, a CUE domain containing 2 protein, plays critical roles in many biological processes, such as cell cycle, inflammation and tumorigenesis. However, whether CUEDC2 was involved in tumorigenesis of glioma and the possible mechanism remains to be elucidated. In the present study, our results implied that the expression of CUEDC2 was lower in the glioma tissue and glioma cell lines than that of normal tissue and asctrocyte cells. Downregulation of endogenous CUEDC2 in glioma U251 cell lines by RNAi promoted the tumor cells proliferation, migration, invasion and glioma neurosphere formation, while, overexpression of CUEDC2 showed the opposite effect. Further studies showed that overexpression of CUEDC2 suppressed the activation and nuclear translocation of phosphorylated-STAT3 (p-STAT3) but the level of p-STAT3 increased after interfering with the expression of CUEDC2. Moreover, CUEDC2 expression has an inhibitory effect on the activation of NF-?B. Thus, our studies suggested that the decreased expression of CUEDC2 in glioma led to the activation of transcription factor STAT3 and NF-?B signaling pathway which may be related to the tumorigenicity in glioma. |Adaptor Proteins, Signal Transducing [MESH] |Apoptosis [MESH] |Biomarkers, Tumor/genetics/*metabolism [MESH] |Carrier Proteins/genetics/*metabolism [MESH] |Cell Proliferation [MESH] |Cell Transformation, Neoplastic/genetics/metabolism/*pathology [MESH] |Follow-Up Studies [MESH] |Glioma/genetics/metabolism/*pathology [MESH] |Humans [MESH] |Membrane Proteins/genetics/*metabolism [MESH] |NF-kappa B/genetics/*metabolism [MESH] |Phosphorylation [MESH] |Prognosis [MESH] |STAT3 Transcription Factor/genetics/*metabolism [MESH] |Signal Transduction [MESH]CUEDC2 suppresses glioma tumorigenicity by inhibiting the activation o(epmc).pdf DeepDyve Pubget Overpricing