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10.3892/ijo.2017.4007 http://scihub22266oqcxt.onion/10.3892/ijo.2017.4007 C5467782!5467782 !28534939     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28534939 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 284.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 284.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 284.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 284.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 284.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28534939 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Int+J+Oncol 2017 ; 51 (1 ): 158-168 Nephropedia Template TP {{tp|p=28534939 |t=2017. miR?181b?5p mediates TGF??1-induced epithelial-to-mesenchymal transition in non-small cell lung cancer stem-like cells derived from lung adenocarcinoma A549 cells |pdf=|usr=}}{{28534939 }} gab.com Text miR 181b 5p mediates TGF 1-induced epithelial-to-mesenchymal transition in non-small cell lung cancer stem-like cells derived from lung adenocarcinoma A549 cells JO: Int J Oncol http://www.kidney.de/pget.php?&tw=1&pmid=28534939 #FOAvip The ability of non-small cell lung cancer (NSCLC) cells to invade and metastasize is associated with epithelial-to-mesenchymal transition (EMT). The process of EMT is, at least in part, regulated by microRNAs. However, it is unknown whether microRNAs regulate EMT in cancer stem-like cells (CSLCs), or which microRNAs are involved. In the present study, we compared microRNA expression in A549 cells, TGF??1-treated A549 cells, CSLCs characterized by the CD133+/CD326+ phenotype, and TGF??1-treated CSLCs. We found that miR?181b?5p expression was upregulated by TGF??1. Moreover, the overexpression of the miR?181b?5p in A549 cells and CD133+/CD326+ cells resulted in the downregulation of the E-cadherin and increased invasion and metastasis in vitro and in vivo. Accordingly, the knockdown of miR?181b?5p partially restored E-cadherin expression. These results suggest that miR?181b?5p regulates TGF??1-induced EMT by targeting E-cadherin not only in normal A549 cells but also in CD133+/CD326+ cells which have characteristics of CSLCs. Thus, miR?181b?5p represents a new therapeutic target in NSCLC. Twit Text FOAVip miR 181b 5p mediates TGF 1-induced epithelial-to-mesenchymal transition in non-small cell lung cancer stem-like cells derived from lung adenocarcinoma A549 cells ????Int J Oncol http://www.kidney.de/pget.php?&tw=1&pmid=28534939 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28534939 #FOAvip English Wikipedia <ref>{{Cite pmid|28534939 }}</ref> miR?181b?5p mediates TGF??1-induced epithelial-to-mesenchymal transition in non-small cell lung cancer stem-like cells derived from lung adenocarcinoma A549 cells #MMPMID28534939 Li X ; Han J ; Zhu H ; Peng L ; Chen Z Int J Oncol 2017[Jul]; 51 (1 ): 158-168 PMID28534939 show ga The ability of non-small cell lung cancer (NSCLC) cells to invade and metastasize is associated with epithelial-to-mesenchymal transition (EMT). The process of EMT is, at least in part, regulated by microRNAs. However, it is unknown whether microRNAs regulate EMT in cancer stem-like cells (CSLCs), or which microRNAs are involved. In the present study, we compared microRNA expression in A549 cells, TGF??1-treated A549 cells, CSLCs characterized by the CD133+/CD326+ phenotype, and TGF??1-treated CSLCs. We found that miR?181b?5p expression was upregulated by TGF??1. Moreover, the overexpression of the miR?181b?5p in A549 cells and CD133+/CD326+ cells resulted in the downregulation of the E-cadherin and increased invasion and metastasis in vitro and in vivo. Accordingly, the knockdown of miR?181b?5p partially restored E-cadherin expression. These results suggest that miR?181b?5p regulates TGF??1-induced EMT by targeting E-cadherin not only in normal A549 cells but also in CD133+/CD326+ cells which have characteristics of CSLCs. Thus, miR?181b?5p represents a new therapeutic target in NSCLC. |*Epithelial-Mesenchymal Transition [MESH] |A549 Cells [MESH] |Adenocarcinoma/genetics/metabolism/*secondary [MESH] |Animals [MESH] |Apoptosis [MESH] |Biomarkers, Tumor [MESH] |Carcinoma, Non-Small-Cell Lung/genetics/metabolism/*secondary [MESH] |Cell Movement [MESH] |Cell Proliferation [MESH] |Female [MESH] |Follow-Up Studies [MESH] |Gene Expression Regulation, Neoplastic [MESH] |Humans [MESH] |Lung Neoplasms/genetics/metabolism/*pathology [MESH] |Male [MESH] |Mice [MESH] |Mice, Nude [MESH] |MicroRNAs/*genetics [MESH] |Middle Aged [MESH] |Neoplasm Invasiveness [MESH] |Neoplasm Metastasis [MESH] |Neoplastic Stem Cells/metabolism/*pathology [MESH] |Prognosis [MESH] |Signal Transduction [MESH] |Transforming Growth Factor beta1/genetics/*metabolism [MESH]miR?181b?5p mediates TGF??1-induced epithelial-to-mesenchymal transiti(epmc).pdf DeepDyve Pubget Overpricing