Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1038/ncb3534 http://scihub22266oqcxt.onion/10.1038/ncb3534 C5467724!5467724 !28530660     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28530660 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28530660 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Nat+Cell+Biol 2017 ; 19 (6 ): 639-652 Nephropedia Template TP {{tp|p=28530660 |t=2017. Endoglin prevents vascular malformation by regulating flow-induced cell migration and specification through VEGFR2 signalling |pdf=|usr=}}{{28530660 }} gab.com Text Endoglin prevents vascular malformation by regulating flow-induced cell migration and specification through VEGFR2 signalling JO: Nat Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=28530660 #FOAvip Loss-of-function (LOF) mutations in the endothelial cell (EC)-enriched gene endoglin (ENG) cause the human disease hereditary haemorrhagic telangiectasia-1, characterized by vascular malformations promoted by vascular endothelial growth factor A (VEGFA). How ENG deficiency alters EC behaviour to trigger these anomalies is not understood. Mosaic ENG deletion in the postnatal mouse rendered Eng LOF ECs insensitive to flow-mediated venous to arterial migration. Eng LOF ECs retained within arterioles acquired venous characteristics and secondary ENG-independent proliferation resulting in arteriovenous malformation (AVM). Analysis following simultaneous Eng LOF and overexpression (OE) revealed that ENG OE ECs dominate tip-cell positions and home preferentially to arteries. ENG knockdown altered VEGFA-mediated VEGFR2 kinetics and promoted AKT signalling. Blockage of PI(3)K/AKT partly normalized flow-directed migration of ENG LOF ECs in vitro and reduced the severity of AVM in vivo. This demonstrates the requirement of ENG in flow-mediated migration and modulation of VEGFR2 signalling in vascular patterning. Twit Text FOAVip Endoglin prevents vascular malformation by regulating flow-induced cell migration and specification through VEGFR2 signalling ????Nat Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=28530660 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28530660 #FOAvip English Wikipedia <ref>{{Cite pmid|28530660 }}</ref> Endoglin prevents vascular malformation by regulating flow-induced cell migration and specification through VEGFR2 signalling #MMPMID28530660 Jin Y ; Muhl L ; Burmakin M ; Wang Y ; Duchez AC ; Betsholtz C ; Arthur HM ; Jakobsson L Nat Cell Biol 2017[Jun]; 19 (6 ): 639-652 PMID28530660 show ga Loss-of-function (LOF) mutations in the endothelial cell (EC)-enriched gene endoglin (ENG) cause the human disease hereditary haemorrhagic telangiectasia-1, characterized by vascular malformations promoted by vascular endothelial growth factor A (VEGFA). How ENG deficiency alters EC behaviour to trigger these anomalies is not understood. Mosaic ENG deletion in the postnatal mouse rendered Eng LOF ECs insensitive to flow-mediated venous to arterial migration. Eng LOF ECs retained within arterioles acquired venous characteristics and secondary ENG-independent proliferation resulting in arteriovenous malformation (AVM). Analysis following simultaneous Eng LOF and overexpression (OE) revealed that ENG OE ECs dominate tip-cell positions and home preferentially to arteries. ENG knockdown altered VEGFA-mediated VEGFR2 kinetics and promoted AKT signalling. Blockage of PI(3)K/AKT partly normalized flow-directed migration of ENG LOF ECs in vitro and reduced the severity of AVM in vivo. This demonstrates the requirement of ENG in flow-mediated migration and modulation of VEGFR2 signalling in vascular patterning. |*Neovascularization, Pathologic [MESH] |*Neovascularization, Physiologic [MESH] |*Signal Transduction [MESH] |Animals [MESH] |Arteriovenous Malformations/genetics/metabolism/pathology/*prevention & control [MESH] |Cell Lineage [MESH] |Cell Proliferation [MESH] |Cells, Cultured [MESH] |Disease Models, Animal [MESH] |Endoglin/deficiency/genetics/*metabolism [MESH] |Endothelial Cells/*metabolism/pathology [MESH] |Genetic Predisposition to Disease [MESH] |Humans [MESH] |Kinetics [MESH] |Mice, Knockout [MESH] |Phenotype [MESH] |Phosphatidylinositol 3-Kinase/metabolism [MESH] |Proto-Oncogene Proteins c-akt/metabolism [MESH] |RNA Interference [MESH] |Stress, Mechanical [MESH] |Telangiectasia, Hereditary Hemorrhagic/genetics/metabolism/pathology/*prevention & control [MESH] |Tissue Culture Techniques [MESH] |Transfection [MESH] |Vascular Endothelial Growth Factor A/metabolism [MESH]Endoglin prevents vascular malformation by regulating flow-induced cel(epmc).pdf DeepDyve Pubget Overpricing