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10.1155/2017/5620314 http://scihub22266oqcxt.onion/10.1155/2017/5620314 C5467347!5467347!28634421     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Mediators+Inflamm 2017 ; 2017 (ä): ä Nephropedia Template TP {{tp|p=28634421|t=2017. The Role of von Willebrand Factor in Vascular Inflammation: From Pathogenesis to Targeted Therapy |pdf=|usr=}}{{28634421}} gab.com Text The Role of von Willebrand Factor in Vascular Inflammation: From Pathogenesis to Targeted Therapy JO: Mediators Inflamm http://www.kidney.de/pget.php?&tw=1&pmid=28634421 #FOAvip Beyond its role in hemostasis, von Willebrand factor (VWF) is an emerging mediator of vascular inflammation. Recent studies highlight the involvement of VWF and its regulator, ADAMTS13, in mechanisms that underlie vascular inflammation and immunothrombosis, like leukocyte rolling, adhesion, and extravasation; vascular permeability; ischemia/reperfusion injury; complements activation; and NETosis. The VWF/ADAMTS13 axis is implicated in the pathogenesis of atherosclerosis, promoting plaque formation and inflammation through macrophage and neutrophil recruitment in inflamed lesions. Moreover, VWF and ADAMTS13 have been recently proposed as prognostic biomarkers in cardiovascular, metabolic, and inflammatory diseases, such as diabetes, stroke, myocardial infarction, and sepsis. All these features make VWF an attractive therapeutic target in thromboinflammation. Several lines of research have recently investigated ?tailor-made? inhibitors of VWF. Results from animal models and clinical studies support the potent anti-inflammatory and antithrombotic effect of VWF antagonism, providing reassuring data on its safety profile. This review describes the role of VWF in vascular inflammation ?from bench to bedside? and provides an updated overview of the drugs that can directly interfere with the VWF/ADAMTS13 axis. Twit Text FOAVip The Role of von Willebrand Factor in Vascular Inflammation: From Pathogenesis to Targeted Therapy ????Mediators Inflamm http://www.kidney.de/pget.php?&tw=1&pmid=28634421 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28634421 #FOAvip English Wikipedia <ref>{{Cite pmid|28634421}}</ref> The Role of von Willebrand Factor in Vascular Inflammation: From Pathogenesis to Targeted Therapy #MMPMID28634421 Gragnano F; Sperlongano S; Golia E; Natale F; Bianchi R; Crisci M; Fimiani F; Pariggiano I; Diana V; Carbone A; Cesaro A; Concilio C; Limongelli G; Russo M; Calabrò P Mediators Inflamm 2017[]; 2017 (ä): ä PMID28634421show ga Beyond its role in hemostasis, von Willebrand factor (VWF) is an emerging mediator of vascular inflammation. Recent studies highlight the involvement of VWF and its regulator, ADAMTS13, in mechanisms that underlie vascular inflammation and immunothrombosis, like leukocyte rolling, adhesion, and extravasation; vascular permeability; ischemia/reperfusion injury; complements activation; and NETosis. The VWF/ADAMTS13 axis is implicated in the pathogenesis of atherosclerosis, promoting plaque formation and inflammation through macrophage and neutrophil recruitment in inflamed lesions. Moreover, VWF and ADAMTS13 have been recently proposed as prognostic biomarkers in cardiovascular, metabolic, and inflammatory diseases, such as diabetes, stroke, myocardial infarction, and sepsis. All these features make VWF an attractive therapeutic target in thromboinflammation. Several lines of research have recently investigated ?tailor-made? inhibitors of VWF. Results from animal models and clinical studies support the potent anti-inflammatory and antithrombotic effect of VWF antagonism, providing reassuring data on its safety profile. This review describes the role of VWF in vascular inflammation ?from bench to bedside? and provides an updated overview of the drugs that can directly interfere with the VWF/ADAMTS13 axis. äThe Role of von Willebrand Factor in Vascular Inflammation: From Patho(epmc).pdf DeepDyve Pubget Overpricing