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2017 ; 2017
(ä): 8139591
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Examination of the Microbial Spectrum in the Etiology of Erythema Nodosum: A
Retrospective Descriptive Study
#MMPMID28634591
Ozbagcivan O
; Akarsu S
; Avci C
; Inci BB
; Fetil E
J Immunol Res
2017[]; 2017
(ä): 8139591
PMID28634591
show ga
Even though infections are the most common cause of erythema nodosum (EN), only
certain microorganisms take the great interest such as streptococci in knowledge.
Our aim was to examine the frequency and type of infections in EN, to determine
the characteristics of patients with an infectious etiology, and to discuss the
role of these microbes in EN pathology in the context of their interactions with
humans. Charts of 81 patients with EN who were seen between 2003 and 2017 were
retrospectively reviewed. Identified etiological factors were classified into
three groups: infectious, noninfectious, and idiopathic. While there were no
significant demographic and clinical differences between the infectious and
idiopathic groups, systemic symptoms (p = 0.034) and the number of EN lesions (p
= 0.016) were significantly lower; the mean erythrocyte sedimentation rate was
significantly higher (p = 0.049), but the mean aspartate aminotransferase value
was significantly lower in the infectious group compared to the noninfectious
group (p = 0.019). Besides streptococci, many other microbes, including the ones
living on and inside us, were identified in the etiology of EN. There is a need
for large-scale prospective studies involving control groups for a better
understanding of the microbial immunopathology of EN.