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10.1038/ncomms15781 http://scihub22266oqcxt.onion/10.1038/ncomms15781 C5467269!5467269!28589929     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Commun 2017 ; 8 (ä): ä Nephropedia Template TP {{tp|p=28589929|t=2017. Type-2 innate lymphoid cells control the development of atherosclerosis in mice |pdf=|usr=}}{{28589929}} gab.com Text Type-2 innate lymphoid cells control the development of atherosclerosis in mice JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=28589929 #FOAvip Type-2 innate lymphoid cells (ILC2) are a prominent source of type II cytokines and are found constitutively at mucosal surfaces and in visceral adipose tissue. Despite their role in limiting obesity, how ILC2s respond to high fat feeding is poorly understood, and their direct influence on the development of atherosclerosis has not been explored. Here, we show that ILC2 are present in para-aortic adipose tissue and lymph nodes and display an inflammatory-like phenotype atypical of adipose resident ILC2. High fat feeding alters both the number of ILC2 and their type II cytokine production. Selective genetic ablation of ILC2 in Ldlr?/? mice accelerates the development of atherosclerosis, which is prevented by reconstitution with wild type but not Il5?/? or Il13?/? ILC2. We conclude that ILC2 represent a major innate cell source of IL-5 and IL-13 required for mounting atheroprotective immunity, which can be altered by high fat diet. Twit Text FOAVip Type-2 innate lymphoid cells control the development of atherosclerosis in mice ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=28589929 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28589929 #FOAvip English Wikipedia <ref>{{Cite pmid|28589929}}</ref> Type-2 innate lymphoid cells control the development of atherosclerosis in mice #MMPMID28589929 Newland SA; Mohanta S; Clément M; Taleb S; Walker JA; Nus M; Sage AP; Yin C; Hu D; Kitt LL; Finigan AJ; Rodewald HR; Binder CJ; McKenzie ANJ; Habenicht AJ; Mallat Z Nat Commun 2017[]; 8 (ä): ä PMID28589929show ga Type-2 innate lymphoid cells (ILC2) are a prominent source of type II cytokines and are found constitutively at mucosal surfaces and in visceral adipose tissue. Despite their role in limiting obesity, how ILC2s respond to high fat feeding is poorly understood, and their direct influence on the development of atherosclerosis has not been explored. Here, we show that ILC2 are present in para-aortic adipose tissue and lymph nodes and display an inflammatory-like phenotype atypical of adipose resident ILC2. High fat feeding alters both the number of ILC2 and their type II cytokine production. Selective genetic ablation of ILC2 in Ldlr?/? mice accelerates the development of atherosclerosis, which is prevented by reconstitution with wild type but not Il5?/? or Il13?/? ILC2. We conclude that ILC2 represent a major innate cell source of IL-5 and IL-13 required for mounting atheroprotective immunity, which can be altered by high fat diet. äType-2 innate lymphoid cells control the development of atherosclerosi(epmc).pdf DeepDyve Pubget Overpricing