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10.1038/ncomms15728 http://scihub22266oqcxt.onion/10.1038/ncomms15728 C5467215!5467215 !28585531     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28585531 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Nat+Commun 2017 ; 8 (ä): 15729 Nephropedia Template TP {{tp|p=28585531 |t=2017. Small extracellular vesicles secreted from senescent cells promote cancer cell proliferation through EphA2 |pdf=|usr=}}{{28585531 }} gab.com Text Small extracellular vesicles secreted from senescent cells promote cancer cell proliferation through EphA2 JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=28585531 #FOAvip Cellular senescence prevents the proliferation of cells at risk for neoplastic transformation. However, the altered secretome of senescent cells can promote the growth of the surrounding cancer cells. Although extracellular vesicles (EVs) have emerged as new players in intercellular communication, their role in the function of senescent cell secretome has been largely unexplored. Here, we show that exosome-like small EVs (sEVs) are important mediators of the pro-tumorigenic function of senescent cells. sEV-associated EphA2 secreted from senescent cells binds to ephrin-A1, that is, highly expressed in several types of cancer cells and promotes cell proliferation through EphA2/ephrin-A1 reverse signalling. sEV sorting of EphA2 is increased in senescent cells because of its enhanced phosphorylation resulting from oxidative inactivation of PTP1B phosphatase. Our results demonstrate a novel mechanism of reactive oxygen species (ROS)-regulated cargo sorting into sEVs, which is critical for the potentially deleterious growth-promoting effect of the senescent cell secretome. Twit Text FOAVip Small extracellular vesicles secreted from senescent cells promote cancer cell proliferation through EphA2 ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=28585531 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28585531 #FOAvip English Wikipedia <ref>{{Cite pmid|28585531 }}</ref> Small extracellular vesicles secreted from senescent cells promote cancer cell proliferation through EphA2 #MMPMID28585531 Takasugi M ; Okada R ; Takahashi A ; Virya Chen D ; Watanabe S ; Hara E Nat Commun 2017[Jun]; 8 (ä): 15729 PMID28585531 show ga Cellular senescence prevents the proliferation of cells at risk for neoplastic transformation. However, the altered secretome of senescent cells can promote the growth of the surrounding cancer cells. Although extracellular vesicles (EVs) have emerged as new players in intercellular communication, their role in the function of senescent cell secretome has been largely unexplored. Here, we show that exosome-like small EVs (sEVs) are important mediators of the pro-tumorigenic function of senescent cells. sEV-associated EphA2 secreted from senescent cells binds to ephrin-A1, that is, highly expressed in several types of cancer cells and promotes cell proliferation through EphA2/ephrin-A1 reverse signalling. sEV sorting of EphA2 is increased in senescent cells because of its enhanced phosphorylation resulting from oxidative inactivation of PTP1B phosphatase. Our results demonstrate a novel mechanism of reactive oxygen species (ROS)-regulated cargo sorting into sEVs, which is critical for the potentially deleterious growth-promoting effect of the senescent cell secretome. |Breast Neoplasms/*metabolism/*pathology [MESH] |Cell Line, Tumor [MESH] |Cell Proliferation [MESH] |Cellular Senescence [MESH] |Ephrin-A2/*metabolism [MESH] |Female [MESH] |Gene Expression Regulation, Neoplastic [MESH] |Humans [MESH] |MCF-7 Cells [MESH] |Mass Spectrometry [MESH] |Oligonucleotide Array Sequence Analysis [MESH] |Ovarian Neoplasms/*metabolism/*pathology [MESH] |Phosphorylation [MESH] |Protein Tyrosine Phosphatase, Non-Receptor Type 1/metabolism [MESH] |Reactive Oxygen Species/metabolism [MESH] |Receptor, EphA2 [MESH] |Recombinant Proteins/metabolism [MESH]Small extracellular vesicles secreted from senescent cells promote can(epmc).pdf DeepDyve Pubget Overpricing