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10.1038/ncomms15180 http://scihub22266oqcxt.onion/10.1038/ncomms15180 C5467167!5467167!28585546     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Commun 2017 ; 8 (ä): ä Nephropedia Template TP {{tp|p=28585546|t=2017. A molecular portrait of microsatellite instability across multiple cancers |pdf=|usr=}}{{28585546}} gab.com Text A molecular portrait of microsatellite instability across multiple cancers JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=28585546 #FOAvip Microsatellite instability (MSI) refers to the hypermutability of short repetitive sequences in the genome caused by impaired DNA mismatch repair. Although MSI has been studied for decades, large amounts of sequencing data now available allows us to examine the molecular fingerprints of MSI in greater detail. Here, we analyse ?8,000 exomes and ?1,000 whole genomes of cancer patients across 23 cancer types. Our analysis reveals that the frequency of MSI events is highly variable within and across tumour types. We also identify genes in DNA repair and oncogenic pathways recurrently subject to MSI and uncover non-coding loci that frequently display MSI. Finally, we propose a highly accurate exome-based predictive model for the MSI phenotype. These results advance our understanding of the genomic drivers and consequences of MSI, and our comprehensive catalogue of tumour-type-specific MSI loci will enable panel-based MSI testing to identify patients who are likely to benefit from immunotherapy. Twit Text FOAVip A molecular portrait of microsatellite instability across multiple cancers ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=28585546 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28585546 #FOAvip English Wikipedia <ref>{{Cite pmid|28585546}}</ref> A molecular portrait of microsatellite instability across multiple cancers #MMPMID28585546 Cortes-Ciriano I; Lee S; Park WY; Kim TM; Park PJ Nat Commun 2017[]; 8 (ä): ä PMID28585546show ga Microsatellite instability (MSI) refers to the hypermutability of short repetitive sequences in the genome caused by impaired DNA mismatch repair. Although MSI has been studied for decades, large amounts of sequencing data now available allows us to examine the molecular fingerprints of MSI in greater detail. Here, we analyse ?8,000 exomes and ?1,000 whole genomes of cancer patients across 23 cancer types. Our analysis reveals that the frequency of MSI events is highly variable within and across tumour types. We also identify genes in DNA repair and oncogenic pathways recurrently subject to MSI and uncover non-coding loci that frequently display MSI. Finally, we propose a highly accurate exome-based predictive model for the MSI phenotype. These results advance our understanding of the genomic drivers and consequences of MSI, and our comprehensive catalogue of tumour-type-specific MSI loci will enable panel-based MSI testing to identify patients who are likely to benefit from immunotherapy. äA molecular portrait of microsatellite instability across multiple can(epmc).pdf DeepDyve Pubget Overpricing