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10.1513/AnnalsATS.201402-050AS http://scihub22266oqcxt.onion/10.1513/AnnalsATS.201402-050AS C5467101!5467101 !25102221     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 296.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 296.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 296.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 296.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25102221 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Ann+Am+Thorac+Soc 2014 ; 11 (7 ): 1120-9 Nephropedia Template TP {{tp|p=25102221 |t=2014. Antibiotic management of lung infections in cystic fibrosis I The microbiome, methicillin-resistant Staphylococcus aureus, gram-negative bacteria, and multiple infections |pdf=|usr=}}{{25102221 }} gab.com Text Antibiotic management of lung infections in cystic fibrosis I The microbiome, methicillin-resistant Staphylococcus aureus, gram-negative bacteria, and multiple infections JO: Ann Am Thorac Soc http://www.kidney.de/pget.php?&tw=1&pmid=25102221 #FOAvip Despite significant advances in treatment strategies targeting the underlying defect in cystic fibrosis (CF), airway infection remains an important cause of lung disease. In this two-part series, we review recent evidence related to the complexity of CF airway infection, explore data suggesting the relevance of individual microbial species, and discuss current and future treatment options. In Part I, the evidence with respect to the spectrum of bacteria present in the CF airway, known as the lung microbiome is discussed. Subsequently, the current approach to treat methicillin-resistant Staphylococcus aureus, gram-negative bacteria, as well as multiple coinfections is reviewed. Newer molecular techniques have demonstrated that the airway microbiome consists of a large number of microbes, and the balance between microbes, rather than the mere presence of a single species, may be relevant for disease pathophysiology. A better understanding of this complex environment could help define optimal treatment regimens that target pathogens without affecting others. Although relevance of these organisms is unclear, the pathologic consequences of methicillin-resistant S. aureus infection in patients with CF have been recently determined. New strategies for eradication and treatment of both acute and chronic infections are discussed. Pseudomonas aeruginosa plays a prominent role in CF lung disease, but many other nonfermenting gram-negative bacteria are also found in the CF airway. Many new inhaled antibiotics specifically targeting P. aeruginosa have become available with the hope that they will improve the quality of life for patients. Part I concludes with a discussion of how best to treat patients with multiple coinfections. Twit Text FOAVip Antibiotic management of lung infections in cystic fibrosis I The microbiome, methicillin-resistant Staphylococcus aureus, gram-negative bacteria, and multiple infections ????Ann Am Thorac Soc http://www.kidney.de/pget.php?&tw=1&pmid=25102221 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25102221 #FOAvip English Wikipedia <ref>{{Cite pmid|25102221 }}</ref> Antibiotic management of lung infections in cystic fibrosis I The microbiome, methicillin-resistant Staphylococcus aureus, gram-negative bacteria, and multiple infections #MMPMID25102221 Chmiel JF ; Aksamit TR ; Chotirmall SH ; Dasenbrook EC ; Elborn JS ; LiPuma JJ ; Ranganathan SC ; Waters VJ ; Ratjen FA Ann Am Thorac Soc 2014[Sep]; 11 (7 ): 1120-9 PMID25102221 show ga Despite significant advances in treatment strategies targeting the underlying defect in cystic fibrosis (CF), airway infection remains an important cause of lung disease. In this two-part series, we review recent evidence related to the complexity of CF airway infection, explore data suggesting the relevance of individual microbial species, and discuss current and future treatment options. In Part I, the evidence with respect to the spectrum of bacteria present in the CF airway, known as the lung microbiome is discussed. Subsequently, the current approach to treat methicillin-resistant Staphylococcus aureus, gram-negative bacteria, as well as multiple coinfections is reviewed. Newer molecular techniques have demonstrated that the airway microbiome consists of a large number of microbes, and the balance between microbes, rather than the mere presence of a single species, may be relevant for disease pathophysiology. A better understanding of this complex environment could help define optimal treatment regimens that target pathogens without affecting others. Although relevance of these organisms is unclear, the pathologic consequences of methicillin-resistant S. aureus infection in patients with CF have been recently determined. New strategies for eradication and treatment of both acute and chronic infections are discussed. Pseudomonas aeruginosa plays a prominent role in CF lung disease, but many other nonfermenting gram-negative bacteria are also found in the CF airway. Many new inhaled antibiotics specifically targeting P. aeruginosa have become available with the hope that they will improve the quality of life for patients. Part I concludes with a discussion of how best to treat patients with multiple coinfections. |Adult [MESH] |Anti-Infective Agents/therapeutic use [MESH] |Child [MESH] |Cystic Fibrosis/complications/*drug therapy/*microbiology [MESH] |Drug Resistance, Bacterial [MESH] |Evidence-Based Medicine [MESH] |Female [MESH] |Gram-Negative Bacteria/drug effects [MESH] |Gram-Negative Bacterial Infections/*drug therapy/microbiology [MESH] |Humans [MESH] |Male [MESH] |Methicillin-Resistant Staphylococcus aureus/*drug effects [MESH] |Microbial Sensitivity Tests [MESH] |Microbiota [MESH] |Prognosis [MESH] |Respiratory Tract Infections/*drug therapy/etiology/microbiology [MESH] |Risk Assessment [MESH] |Staphylococcal Infections/*drug therapy/etiology [MESH]Antibiotic management of lung infections in cystic fibrosis I The mi(epmc).pdf DeepDyve Pubget Overpricing