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2017 ; 23
(21
): 3915-3927
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gab.com Text
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English Wikipedia
Epidemiology of functional gastrointestinal disorders in children and
adolescents: A systematic review
#MMPMID28638232
Boronat AC
; Ferreira-Maia AP
; Matijasevich A
; Wang YP
World J Gastroenterol
2017[Jun]; 23
(21
): 3915-3927
PMID28638232
show ga
AIM: To assess the prevalence of functional gastrointestinal disorders (FGIDs) in
children and adolescents. METHODS: PubMed, EMBASE, and Scopus databases were
searched for original articles from inception to September 2016. The literature
search was made in accordance with the Preferred Reporting Items for Systematic
Reviews and Meta-Analyses (PRISMA) recommendations. For inclusion, each study had
to report epidemiological data on FGIDs in children between 4 and 18 years old
and contain standardized outcome based on Rome II, III or IV criteria. The
overall quality of included epidemiological studies was evaluated in accordance
with Loney's proposal for prevalence studies of health literature. Two reviewers
assessed each study for data inclusion and extraction. Discrepancies were
reconciled through discussion with seniors. RESULTS: A total of 659 articles were
identified from the databases and 16 through manual search. A total of 43
articles fulfilled the eligibility criteria for full-text reading, with 26
remaining to be included in the final analysis. All studies were written in
English and published between 2005 and 2016. Eight (30.8%) articles were
performed in North America, five (19.2%) in Latin America, five (19.2%) in
Europe, seven (27%) in Asia, and one (3.8%) in Africa. Sample size varied between
114 and 99416 subjects, totaling 132600 individuals. Fourteen (53.9%) studies
recruited their target samples from schools, 11 (42.3%) from healthcare settings
and the remaining one (3.8%) from online panel community. The overall FGID
prevalence rates for student samples ranged from 9.9% to 29% to as high as 87% in
clinical samples. Cyclic vomiting, irritable bowel syndrome and functional
constipation were the most researched conditions, with a prevalence ranging from
0.2% to 6.2%, 0% to 45.1% and 0.5% to 86.9%, respectively. The qualitative
appraisal revealed that most of the studies showed average or below average
generalizability. CONCLUSION: The heterogeneity of the studies on FGIDs must be
improved in order to allow comparison. Improvements should include appropriate
sampling of representative population, comparable study setting, and consistent
data collection.