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10.1038/nm.4308 http://scihub22266oqcxt.onion/10.1038/nm.4308 C5466900!5466900 !28346412     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28346412 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Nat+Med 2017 ; 23 (5 ): 551-555 Nephropedia Template TP {{tp|p=28346412 |t=2017. VISTA is an inhibitory immune checkpoint that is increased after ipilimumab therapy in patients with prostate cancer |pdf=|usr=}}{{28346412 }} gab.com Text VISTA is an inhibitory immune checkpoint that is increased after ipilimumab therapy in patients with prostate cancer JO: Nat Med http://www.kidney.de/pget.php?&tw=1&pmid=28346412 #FOAvip To date, anti-CTLA-4 (ipilimumab) or anti-PD-1 (nivolumab) monotherapy has not been demonstrated to be of substantial clinical benefit in patients with prostate cancer. To identify additional immune-inhibitory pathways in the prostate-tumor microenvironment, we evaluated untreated and ipilimumab-treated tumors from patients in a presurgical clinical trial. Levels of the PD-L1 and VISTA inhibitory molecules increased on independent subsets of macrophages in treated tumors. Our data suggest that VISTA represents another compensatory inhibitory pathway in prostate tumors after ipilimumab therapy. Twit Text FOAVip VISTA is an inhibitory immune checkpoint that is increased after ipilimumab therapy in patients with prostate cancer ????Nat Med http://www.kidney.de/pget.php?&tw=1&pmid=28346412 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28346412 #FOAvip English Wikipedia <ref>{{Cite pmid|28346412 }}</ref> VISTA is an inhibitory immune checkpoint that is increased after ipilimumab therapy in patients with prostate cancer #MMPMID28346412 Gao J ; Ward JF ; Pettaway CA ; Shi LZ ; Subudhi SK ; Vence LM ; Zhao H ; Chen J ; Chen H ; Efstathiou E ; Troncoso P ; Allison JP ; Logothetis CJ ; Wistuba II ; Sepulveda MA ; Sun J ; Wargo J ; Blando J ; Sharma P Nat Med 2017[May]; 23 (5 ): 551-555 PMID28346412 show ga To date, anti-CTLA-4 (ipilimumab) or anti-PD-1 (nivolumab) monotherapy has not been demonstrated to be of substantial clinical benefit in patients with prostate cancer. To identify additional immune-inhibitory pathways in the prostate-tumor microenvironment, we evaluated untreated and ipilimumab-treated tumors from patients in a presurgical clinical trial. Levels of the PD-L1 and VISTA inhibitory molecules increased on independent subsets of macrophages in treated tumors. Our data suggest that VISTA represents another compensatory inhibitory pathway in prostate tumors after ipilimumab therapy. |Adenocarcinoma/*drug therapy/immunology/metabolism [MESH] |Adult [MESH] |Aged [MESH] |Animals [MESH] |Antibodies, Monoclonal/*therapeutic use [MESH] |Antineoplastic Agents/*therapeutic use [MESH] |B7 Antigens/immunology/*metabolism [MESH] |B7-H1 Antigen/immunology/*metabolism [MESH] |Cell Line, Tumor [MESH] |Disease Models, Animal [MESH] |Flow Cytometry [MESH] |Fluorescent Antibody Technique [MESH] |Humans [MESH] |Immunohistochemistry [MESH] |In Vitro Techniques [MESH] |Ipilimumab [MESH] |Macrophages/immunology/*metabolism [MESH] |Male [MESH] |Membrane Proteins/immunology/metabolism [MESH] |Mice [MESH] |Middle Aged [MESH] |Neoadjuvant Therapy [MESH] |Prostatectomy [MESH] |Prostatic Neoplasms/*drug therapy/immunology/metabolism [MESH] |T-Lymphocytes [MESH]VISTA is an inhibitory immune checkpoint that is increased after ipili(epmc).pdf DeepDyve Pubget Overpricing