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10.1016/j.celrep.2017.02.070 http://scihub22266oqcxt.onion/10.1016/j.celrep.2017.02.070 C5466819!5466819 !28355564     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28355564 &cmd=llinks): Failed to open stream: HTTP request failed! 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SMARCAD1 Contributes to the Regulation of Naive Pluripotency by Interacting with Histone Citrullination |pdf=|usr=}}{{28355564 }} gab.com Text SMARCAD1 Contributes to the Regulation of Naive Pluripotency by Interacting with Histone Citrullination JO: Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=28355564 #FOAvip Histone citrullination regulates diverse cellular processes. Here, we report that SMARCAD1 preferentially associates with H3 arginine 26 citrullination (H3R26Cit) peptides present on arrays composed of 384 histone peptides harboring distinct post-transcriptional modifications. Among ten histone modifications assayed by ChIP-seq, H3R26Cit exhibited the most extensive genomewide co-localization with SMARCAD1 binding. Increased Smarcad1 expression correlated with naive pluripotency in pre-implantation embryos. In the presence of LIF, Smarcad1 knockdown (KD) embryonic stem cells lost naive state phenotypes but remained pluripotent, as suggested by morphology, gene expression, histone modifications, alkaline phosphatase activity, energy metabolism, embryoid bodies, teratoma, and chimeras. The majority of H3R26Cit ChIP-seq peaks occupied by SMARCAD1 were associated with increased levels of H3K9me3 in Smarcad1 KD cells. Inhibition of H3Cit induced H3K9me3 at the overlapping regions of H3R26Cit peaks and SMARCAD1 peaks. These data suggest a model in which SMARCAD1 regulates naive pluripotency by interacting with H3R26Cit and suppressing heterochromatin formation. Twit Text FOAVip SMARCAD1 Contributes to the Regulation of Naive Pluripotency by Interacting with Histone Citrullination ????Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=28355564 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28355564 #FOAvip English Wikipedia <ref>{{Cite pmid|28355564 }}</ref> SMARCAD1 Contributes to the Regulation of Naive Pluripotency by Interacting with Histone Citrullination #MMPMID28355564 Xiao S ; Lu J ; Sridhar B ; Cao X ; Yu P ; Zhao T ; Chen CC ; McDee D ; Sloofman L ; Wang Y ; Rivas-Astroza M ; Telugu BPVL ; Levasseur D ; Zhang K ; Liang H ; Zhao JC ; Tanaka TS ; Stormo G ; Zhong S Cell Rep 2017[Mar]; 18 (13 ): 3117-3128 PMID28355564 show ga Histone citrullination regulates diverse cellular processes. Here, we report that SMARCAD1 preferentially associates with H3 arginine 26 citrullination (H3R26Cit) peptides present on arrays composed of 384 histone peptides harboring distinct post-transcriptional modifications. Among ten histone modifications assayed by ChIP-seq, H3R26Cit exhibited the most extensive genomewide co-localization with SMARCAD1 binding. Increased Smarcad1 expression correlated with naive pluripotency in pre-implantation embryos. In the presence of LIF, Smarcad1 knockdown (KD) embryonic stem cells lost naive state phenotypes but remained pluripotent, as suggested by morphology, gene expression, histone modifications, alkaline phosphatase activity, energy metabolism, embryoid bodies, teratoma, and chimeras. The majority of H3R26Cit ChIP-seq peaks occupied by SMARCAD1 were associated with increased levels of H3K9me3 in Smarcad1 KD cells. Inhibition of H3Cit induced H3K9me3 at the overlapping regions of H3R26Cit peaks and SMARCAD1 peaks. These data suggest a model in which SMARCAD1 regulates naive pluripotency by interacting with H3R26Cit and suppressing heterochromatin formation. |*Citrullination [MESH] |Animals [MESH] |Base Sequence [MESH] |Binding Sites [MESH] |Cells, Cultured [MESH] |Chromatin/metabolism [MESH] |DNA Helicases [MESH] |Embryo, Mammalian/metabolism [MESH] |Embryonic Development [MESH] |Embryonic Stem Cells/metabolism [MESH] |Epigenesis, Genetic [MESH] |Female [MESH] |Gene Knockdown Techniques [MESH] |Genome [MESH] |Histones/*metabolism [MESH] |Lysine/metabolism [MESH] |Male [MESH] |Methylation [MESH] |Mice [MESH] |Nuclear Proteins/*metabolism [MESH] |Phenotype [MESH] |Pluripotent Stem Cells/*metabolism [MESH] |Protein Binding [MESH] |Protein Processing, Post-Translational [MESH]SMARCAD1 Contributes to the Regulation of Naive Pluripotency by Intera(epmc).pdf DeepDyve Pubget Overpricing