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10.1016/j.cobeha.2015.01.004 http://scihub22266oqcxt.onion/10.1016/j.cobeha.2015.01.004 C5466806!5466806!28607947     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Curr+Opin+Behav+Sci 2015 ; 4 (ä): 22-6 Nephropedia Template TP {{tp|p=28607947|t=2015. Behavioral-Cognitive Targets for Cholinergic Enhancement |pdf=|usr=}}{{28607947}} gab.com Text Behavioral-Cognitive Targets for Cholinergic Enhancement JO: Curr Opin Behav Sci http://www.kidney.de/pget.php?&tw=1&pmid=28607947 #FOAvip Cholinergic mechanisms have long been considered a promising target for enhancing cognitive functions. Two distinct yet interacting components of cholinergic activity have been proposed to mediate specific cognitive functions. Transient spikes in cholinergic activity mediate the detection of cues in situations involving attentional mode shifts. More slowly changing cholinergic neuromodulation of cortical circuitry regulates task compliance specifically in response to performance challenges. Increases in cholinergic neuromodulation enhances the generation of cholinergic transients via stimulation of ?4?2* nicotinic acetylcholine receptors. Stimulation of these receptors stabilizes attentional performance and increases cue detection rates. Adjunctive treatment with agonists or modulators at these receptors is predicted to benefit unstable attentional performance and low cue detection rates that are common to several brain disorders. Twit Text FOAVip Behavioral-Cognitive Targets for Cholinergic Enhancement ????Curr Opin Behav Sci http://www.kidney.de/pget.php?&tw=1&pmid=28607947 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28607947 #FOAvip English Wikipedia <ref>{{Cite pmid|28607947}}</ref> Behavioral-Cognitive Targets for Cholinergic Enhancement #MMPMID28607947 Sarter M Curr Opin Behav Sci 2015[Aug]; 4 (ä): 22-6 PMID28607947show ga Cholinergic mechanisms have long been considered a promising target for enhancing cognitive functions. Two distinct yet interacting components of cholinergic activity have been proposed to mediate specific cognitive functions. Transient spikes in cholinergic activity mediate the detection of cues in situations involving attentional mode shifts. More slowly changing cholinergic neuromodulation of cortical circuitry regulates task compliance specifically in response to performance challenges. Increases in cholinergic neuromodulation enhances the generation of cholinergic transients via stimulation of ?4?2* nicotinic acetylcholine receptors. Stimulation of these receptors stabilizes attentional performance and increases cue detection rates. Adjunctive treatment with agonists or modulators at these receptors is predicted to benefit unstable attentional performance and low cue detection rates that are common to several brain disorders. äBehavioral-Cognitive Targets for Cholinergic Enhancement (epmc).pdf DeepDyve Pubget Overpricing