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Cancer-derived exosomic microRNAs shape the immune system within the tumor
microenvironment: State of the art
#MMPMID27956165
Fanini F
; Fabbri M
Semin Cell Dev Biol
2017[Jul]; 67
(?): 23-28
PMID27956165
show ga
In recent years there has been an increasing interest of the scientific community
on exosome research, with particular emphasis on the mechanisms by which
tumor-derived exosomes can promote tumor growth. Particularly, exosome-mediated
immune-escape is under deep investigation and still represents a quite
controversial issue. Tumor-derived exosomes are carriers of information able to
reprogram functions of immune target cells, influencing their development,
maturation, and antitumor activities. They deliver proteins similar to those of
the parent cancer cells, but also genetic messages like genomic DNA, mRNA, and
microRNAs (miRNAs) that ultimately share the so called "tumor microenvironment"
in a pro-tumoral fashion. The content of tumor-derived exosomes could be
implicated in several signaling pathways operating in the tumor microenvironment,
providing a further modality of dys-regulation of antitumor immunity. The aim of
this review is to provide a state-of-the-art highlight of to the most recent
discoveries in the field of interaction between tumor-derived exosomic miRNAs and
the cells of immune system.
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