Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.7554/eLife.23499 http://scihub22266oqcxt.onion/10.7554/eLife.23499 C5466420!5466420 !28492365     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28492365 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Elife 2017 ; 6 (ä): ä Nephropedia Template TP {{tp|p=28492365 |t=2017. The Hippo pathway effector YAP is an essential regulator of ductal progenitor patterning in the mouse submandibular gland |pdf=|usr=}}{{28492365 }} gab.com Text The Hippo pathway effector YAP is an essential regulator of ductal progenitor patterning in the mouse submandibular gland JO: Elife http://www.kidney.de/pget.php?&tw=1&pmid=28492365 #FOAvip Salivary glands, such as submandibular glands (SMGs), are composed of branched epithelial ductal networks that terminate in acini that together produce, transport and secrete saliva. Here, we show that the transcriptional regulator Yap, a key effector of the Hippo pathway, is required for the proper patterning and morphogenesis of SMG epithelium. Epithelial deletion of Yap in developing SMGs results in the loss of ductal structures, arising from reduced expression of the EGF family member Epiregulin, which we show is required for the expansion of Krt5/Krt14-positive ductal progenitors. We further show that epithelial deletion of the Lats1 and Lats2 genes, which encode kinases that restrict nuclear Yap localization, results in morphogenesis defects accompanied by an expansion of Krt5/Krt14-positive cells. Collectively, our data indicate that Yap-induced Epiregulin signaling promotes the identity of SMG ductal progenitors and that removal of nuclear Yap by Lats1/2-mediated signaling is critical for proper ductal maturation. Twit Text FOAVip The Hippo pathway effector YAP is an essential regulator of ductal progenitor patterning in the mouse submandibular gland ????Elife http://www.kidney.de/pget.php?&tw=1&pmid=28492365 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28492365 #FOAvip English Wikipedia <ref>{{Cite pmid|28492365 }}</ref> The Hippo pathway effector YAP is an essential regulator of ductal progenitor patterning in the mouse submandibular gland #MMPMID28492365 Szymaniak AD ; Mi R ; McCarthy SE ; Gower AC ; Reynolds TL ; Mingueneau M ; Kukuruzinska M ; Varelas X Elife 2017[May]; 6 (ä): ä PMID28492365 show ga Salivary glands, such as submandibular glands (SMGs), are composed of branched epithelial ductal networks that terminate in acini that together produce, transport and secrete saliva. Here, we show that the transcriptional regulator Yap, a key effector of the Hippo pathway, is required for the proper patterning and morphogenesis of SMG epithelium. Epithelial deletion of Yap in developing SMGs results in the loss of ductal structures, arising from reduced expression of the EGF family member Epiregulin, which we show is required for the expansion of Krt5/Krt14-positive ductal progenitors. We further show that epithelial deletion of the Lats1 and Lats2 genes, which encode kinases that restrict nuclear Yap localization, results in morphogenesis defects accompanied by an expansion of Krt5/Krt14-positive cells. Collectively, our data indicate that Yap-induced Epiregulin signaling promotes the identity of SMG ductal progenitors and that removal of nuclear Yap by Lats1/2-mediated signaling is critical for proper ductal maturation. |*Morphogenesis [MESH] |Adaptor Proteins, Signal Transducing/*metabolism [MESH] |Animals [MESH] |Body Patterning [MESH] |Cell Cycle Proteins [MESH] |Epiregulin/*metabolism [MESH] |Epithelium/*embryology [MESH] |Gene Deletion [MESH] |Mice, Inbred C57BL [MESH] |Phosphoproteins/*metabolism [MESH] |Protein Serine-Threonine Kinases/genetics/*metabolism [MESH] |Signal Transduction [MESH] |Stem Cells/physiology [MESH] |Submandibular Gland/*embryology [MESH] |Tumor Suppressor Proteins/genetics/*metabolism [MESH]The Hippo pathway effector YAP is an essential regulator of ductal pro(epmc).pdf DeepDyve Pubget Overpricing