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10.1371/journal.pone.0179204 http://scihub22266oqcxt.onion/10.1371/journal.pone.0179204 C5466328!5466328 !28598982     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28598982 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28598982 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       PLoS+One 2017 ; 12 (6 ): e0179204 Nephropedia Template TP {{tp|p=28598982 |t=2017. ?-Mangostin ameliorates hepatic steatosis and insulin resistance by inhibition C-C chemokine receptor 2 |pdf=|usr=}}{{28598982 }} gab.com Text -Mangostin ameliorates hepatic steatosis and insulin resistance by inhibition C-C chemokine receptor 2 JO: PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=28598982 #FOAvip Obesity induces various metabolic diseases such as dyslipidemia, nonalcoholic fatty liver disease (NAFLD), and type 2 diabetes. Fat expansion in adipose tissue induces adipose tissue dysfunction and inflammation, insulin resistance, and other metabolic syndromes. ?-Mangostin (?-MG) has been previously studied for its anti-cancer, anti-inflammatory, and antioxidant activities. In this study, we investigated the effects of ?-MG on adipose tissue inflammation and hepatic steatosis. We categorized study animals into four groups: regular diet control mice, RD mice treated with ?-MG, high fat diet-induced obese mice, and HFD mice treated with ?-MG. ?-MG treatment significantly reduced not only the body, liver, and fat weights, but also plasma glucose, insulin, and triglyceride levels in HFD mice. Additionally, adiponectin levels of ?-MG-treated mice were significantly higher than those of control HFD mice. Immunohistochemistry of liver and adipose tissue showed that CD11c expression was reduced in ?-MG fed obese mice. ?-MG treatment of HFD mice down-regulated the adipose-associated inflammatory cytokines and CCR2 in both liver and adipose tissue. Moreover, glucose tolerance and insulin sensitivity were significantly improved in ?-MG fed obese mice. ?-Mangostin ameliorates adipose inflammation and hepatic steatosis in HFD-induced obese mice. Twit Text FOAVip -Mangostin ameliorates hepatic steatosis and insulin resistance by inhibition C-C chemokine receptor 2 ????PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=28598982 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28598982 #FOAvip English Wikipedia <ref>{{Cite pmid|28598982 }}</ref> ?-Mangostin ameliorates hepatic steatosis and insulin resistance by inhibition C-C chemokine receptor 2 #MMPMID28598982 Kim HM ; Kim YM ; Huh JH ; Lee ES ; Kwon MH ; Lee BR ; Ko HJ ; Chung CH PLoS One 2017[]; 12 (6 ): e0179204 PMID28598982 show ga Obesity induces various metabolic diseases such as dyslipidemia, nonalcoholic fatty liver disease (NAFLD), and type 2 diabetes. Fat expansion in adipose tissue induces adipose tissue dysfunction and inflammation, insulin resistance, and other metabolic syndromes. ?-Mangostin (?-MG) has been previously studied for its anti-cancer, anti-inflammatory, and antioxidant activities. In this study, we investigated the effects of ?-MG on adipose tissue inflammation and hepatic steatosis. We categorized study animals into four groups: regular diet control mice, RD mice treated with ?-MG, high fat diet-induced obese mice, and HFD mice treated with ?-MG. ?-MG treatment significantly reduced not only the body, liver, and fat weights, but also plasma glucose, insulin, and triglyceride levels in HFD mice. Additionally, adiponectin levels of ?-MG-treated mice were significantly higher than those of control HFD mice. Immunohistochemistry of liver and adipose tissue showed that CD11c expression was reduced in ?-MG fed obese mice. ?-MG treatment of HFD mice down-regulated the adipose-associated inflammatory cytokines and CCR2 in both liver and adipose tissue. Moreover, glucose tolerance and insulin sensitivity were significantly improved in ?-MG fed obese mice. ?-Mangostin ameliorates adipose inflammation and hepatic steatosis in HFD-induced obese mice. |*Insulin Resistance [MESH] |Adipose Tissue/drug effects/metabolism [MESH] |Animals [MESH] |Body Weight/drug effects [MESH] |Bone Marrow Cells/cytology/immunology/metabolism [MESH] |Cell Line [MESH] |Cytokines/metabolism [MESH] |Diet, High-Fat [MESH] |Disease Models, Animal [MESH] |Fatty Acids/biosynthesis [MESH] |Glucose Tolerance Test [MESH] |Inflammation Mediators/metabolism [MESH] |Liver/drug effects/metabolism [MESH] |Macrophages/drug effects/immunology/metabolism [MESH] |Mice [MESH] |Non-alcoholic Fatty Liver Disease/drug therapy/etiology/*metabolism [MESH] |Obesity/drug therapy/etiology/metabolism [MESH] |Protein Kinase Inhibitors/*pharmacology [MESH] |Receptors, CCR2/*antagonists & inhibitors/*metabolism [MESH]?-Mangostin ameliorates hepatic steatosis and insulin resistance by in(epmc).pdf DeepDyve Pubget Overpricing