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10.1016/j.celrep.2017.03.024 http://scihub22266oqcxt.onion/10.1016/j.celrep.2017.03.024 C5465952!5465952!28380356     free     free     free Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Rep 2017 ; 19 (1): 175-87 Nephropedia Template TP {{tp|p=28380356|t=2017. Necroptosis Execution Is Mediated by Plasma Membrane Nanopores Independent of Calcium |pdf=|usr=}}{{28380356}} gab.com Text Necroptosis Execution Is Mediated by Plasma Membrane Nanopores Independent of Calcium JO: Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=28380356 #FOAvip Necroptosis is a form of regulated necrosis that results in cell death and content release after plasma membrane permeabilization. However, little is known about the molecular events responsible for the disruption of the plasma membrane. Here, we find that early increase in cytosolic calcium in TNF-induced necroptosis is mediated by treatment with a Smac mimetic via the TNF/RIP1/TAK1 survival pathway. This does not require the activation of the necrosome and is dispensable for necroptosis. Necroptosis induced by the activation of TLR3/4 pathways does not trigger early calcium flux. We also demonstrate that necroptotic plasma membrane rupture is mediated by osmotic forces and membrane pores around 4 nm in diameter. This late permeabilization step represents a hallmark in necroptosis execution that is cell and treatment independent and requires the RIP1/RIP3/MLKL core. In support of this, treatment with osmoprotectants reduces cell damage in an in vivo necroptosis model of ischemia-reperfusion injury. Twit Text FOAVip Necroptosis Execution Is Mediated by Plasma Membrane Nanopores Independent of Calcium ????Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=28380356 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28380356 #FOAvip English Wikipedia <ref>{{Cite pmid|28380356}}</ref> Necroptosis Execution Is Mediated by Plasma Membrane Nanopores Independent of Calcium #MMPMID28380356 Ros U; Peña-Blanco A; Hänggi K; Kunzendorf U; Krautwald S; Wong WWL; García-Sáez AJ Cell Rep 2017[Apr]; 19 (1): 175-87 PMID28380356show ga Necroptosis is a form of regulated necrosis that results in cell death and content release after plasma membrane permeabilization. However, little is known about the molecular events responsible for the disruption of the plasma membrane. Here, we find that early increase in cytosolic calcium in TNF-induced necroptosis is mediated by treatment with a Smac mimetic via the TNF/RIP1/TAK1 survival pathway. This does not require the activation of the necrosome and is dispensable for necroptosis. Necroptosis induced by the activation of TLR3/4 pathways does not trigger early calcium flux. We also demonstrate that necroptotic plasma membrane rupture is mediated by osmotic forces and membrane pores around 4 nm in diameter. This late permeabilization step represents a hallmark in necroptosis execution that is cell and treatment independent and requires the RIP1/RIP3/MLKL core. In support of this, treatment with osmoprotectants reduces cell damage in an in vivo necroptosis model of ischemia-reperfusion injury. äNecroptosis Execution Is Mediated by Plasma Membrane Nanopores Indepen(epmc).pdf DeepDyve Pubget Overpricing