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10.1073/pnas.1618446114 http://scihub22266oqcxt.onion/10.1073/pnas.1618446114 C5465915!5465915 !28507145     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28507145 &cmd=llinks): Failed to open stream: HTTP request failed! 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In vivo photolabeling of tumor-infiltrating cells reveals highly regulated egress of T-cell subsets from tumors |pdf=|usr=}}{{28507145 }} gab.com Text In vivo photolabeling of tumor-infiltrating cells reveals highly regulated egress of T-cell subsets from tumors JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=28507145 #FOAvip Immune therapy is rapidly gaining prominence in the clinic as a major weapon against cancer. Whereas much attention has been focused on the infiltration of tumors by immune cells, the subsequent fate of these infiltrates remains largely unexplored. We therefore established a photoconversion-based model that allowed us to label tumor-infiltrating immune cells and follow their migration. Using this system, we identified a population of tumor-experienced cells that emigrate from primary tumors to draining lymph nodes via afferent lymphatic vessels. Although the majority of tumor-infiltrating cells were myeloid, T cells made up the largest population of tumor-egressing leukocytes. Strikingly, the subset composition of tumor-egressing T cells was greatly skewed compared with those that had infiltrated the tumor and those resident in the draining lymph node. Some T-cell subsets such as CD8(+) T cells emigrated more readily; others including CD4(-)CD8(-) T cells were preferentially retained, suggesting that specific mechanisms guide immune cell egress from tumors. Furthermore, tumor-egressing T cells were more activated and displayed enhanced effector function in comparison with their lymph node counterparts. Finally, we demonstrated that tumor-infiltrating T cells migrate to distant secondary tumors and draining lymph nodes, highlighting a mechanism whereby tumor-experienced effector T cells may mediate antitumor immunity at metastatic sites. Thus, our results provide insights into migration and function of tumor-infiltrating immune cells and the role of these cells in tumor immunity outside of primary tumor deposits. Twit Text FOAVip In vivo photolabeling of tumor-infiltrating cells reveals highly regulated egress of T-cell subsets from tumors ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=28507145 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28507145 #FOAvip English Wikipedia <ref>{{Cite pmid|28507145 }}</ref> In vivo photolabeling of tumor-infiltrating cells reveals highly regulated egress of T-cell subsets from tumors #MMPMID28507145 Torcellan T ; Hampton HR ; Bailey J ; Tomura M ; Brink R ; Chtanova T Proc Natl Acad Sci U S A 2017[May]; 114 (22 ): 5677-5682 PMID28507145 show ga Immune therapy is rapidly gaining prominence in the clinic as a major weapon against cancer. Whereas much attention has been focused on the infiltration of tumors by immune cells, the subsequent fate of these infiltrates remains largely unexplored. We therefore established a photoconversion-based model that allowed us to label tumor-infiltrating immune cells and follow their migration. Using this system, we identified a population of tumor-experienced cells that emigrate from primary tumors to draining lymph nodes via afferent lymphatic vessels. Although the majority of tumor-infiltrating cells were myeloid, T cells made up the largest population of tumor-egressing leukocytes. Strikingly, the subset composition of tumor-egressing T cells was greatly skewed compared with those that had infiltrated the tumor and those resident in the draining lymph node. Some T-cell subsets such as CD8(+) T cells emigrated more readily; others including CD4(-)CD8(-) T cells were preferentially retained, suggesting that specific mechanisms guide immune cell egress from tumors. Furthermore, tumor-egressing T cells were more activated and displayed enhanced effector function in comparison with their lymph node counterparts. Finally, we demonstrated that tumor-infiltrating T cells migrate to distant secondary tumors and draining lymph nodes, highlighting a mechanism whereby tumor-experienced effector T cells may mediate antitumor immunity at metastatic sites. Thus, our results provide insights into migration and function of tumor-infiltrating immune cells and the role of these cells in tumor immunity outside of primary tumor deposits. |Animals [MESH] |CD8-Positive T-Lymphocytes/*immunology [MESH] |Carcinoma, Lewis Lung/*immunology [MESH] |Cell Line, Tumor [MESH] |Cell Movement/*immunology [MESH] |Dendritic Cells/immunology [MESH] |Immunotherapy, Adoptive/methods [MESH] |Lymph Nodes/cytology/immunology [MESH] |Lymphocyte Activation/*immunology [MESH] |Lymphocytes, Tumor-Infiltrating/*immunology [MESH] |Macrophages/immunology [MESH] |Mice [MESH] |Mice, Inbred C57BL [MESH] |Mice, Knockout [MESH] |Neutrophils/immunology [MESH]In vivo photolabeling of tumor-infiltrating cells reveals highly regul(epmc).pdf DeepDyve Pubget Overpricing