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10.2169/internalmedicine.56.7742

http://scihub22266oqcxt.onion/10.2169/internalmedicine.56.7742
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suck abstract from ncbi


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pmid28420847
      Intern+Med 2017 ; 56 (8 ): 959-965
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  • The Successful Treatment of Myeloperoxidase Antineutrophil Cytoplasmic Antibody-positive Hypertrophic Pachymeningitis in Patients with the Limited Form of Granulomatosis with Polyangiitis Using Methotrexate: Two Case Reports #MMPMID28420847
  • Kaieda S ; Yoshida N ; Minezaki M ; Ushijima S ; Wakasugi D ; Miura S ; Uchiyama Y ; Ida H ; Hoshino T
  • Intern Med 2017[]; 56 (8 ): 959-965 PMID28420847 show ga
  • Recent findings have indicated a close relationship between myeloperoxidase antineutrophil cytoplasmic antibody (MPO-ANCA)-positive hypertrophic pachymeningitis and the limited form of granulomatosis with polyangiitis (GPA). In Japan, MPO-ANCA-positive hypertrophic pachymeningitis predominantly occurs in elderly individuals. We herein describe the cases of two patients with MPO-ANCA-positive hypertrophic pachymeningitis associated with the limited form of GPA who were successfully treated with a combination of corticosteroids and methotrexate. Although methotrexate has been shown to be less effective than cyclophosphamide for inducing the remission of GPA in patients with organ-threatening diseases, its safety and efficacy may make it a useful alternative treatment modality for patients with the limited form of GPA who show meningeal involvement.
  • |Aged [MESH]
  • |Antibodies, Antineutrophil Cytoplasmic/immunology [MESH]
  • |Female [MESH]
  • |Granulomatosis with Polyangiitis/*complications [MESH]
  • |Humans [MESH]
  • |Hypertrophy/complications [MESH]
  • |Immunosuppressive Agents/*therapeutic use [MESH]
  • |Meningitis/complications/*drug therapy [MESH]
  • |Methotrexate/*therapeutic use [MESH]
  • |Middle Aged [MESH]


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