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10.1038/ncomms15632 http://scihub22266oqcxt.onion/10.1038/ncomms15632 C5465362!5465362!28580944     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Commun 2017 ; 8 (ä): ä Nephropedia Template TP {{tp|p=28580944|t=2017. IL-17-producing ?? T cells switch migratory patterns between resting and activated states |pdf=|usr=}}{{28580944}} gab.com Text IL-17-producing T cells switch migratory patterns between resting and activated states JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=28580944 #FOAvip Interleukin 17-producing ?? T (??T17) cells have unconventional trafficking characteristics, residing in mucocutaneous tissues but also homing into inflamed tissues via circulation. Despite being fundamental to ??T17-driven early protective immunity and exacerbation of autoimmunity and cancer, migratory cues controlling ??T17 cell positioning in barrier tissues and recruitment to inflammatory sites are still unclear. Here we show that ??T17 cells constitutively express chemokine receptors CCR6 and CCR2. While CCR6 recruits resting ??T17 cells to the dermis, CCR2 drives rapid ??T17 cell recruitment to inflamed tissues during autoimmunity, cancer and infection. Downregulation of CCR6 by IRF4 and BATF upon ??T17 activation is required for optimal recruitment of ??T17 cells to inflamed tissue by preventing their sequestration into uninflamed dermis. These findings establish a lymphocyte trafficking model whereby a hierarchy of homing signals is prioritized by dynamic receptor expression to drive both tissue surveillance and rapid recruitment of ??T17 cells to inflammatory lesions. Twit Text FOAVip IL-17-producing T cells switch migratory patterns between resting and activated states ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=28580944 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28580944 #FOAvip English Wikipedia <ref>{{Cite pmid|28580944}}</ref> IL-17-producing ?? T cells switch migratory patterns between resting and activated states #MMPMID28580944 McKenzie DR; Kara EE; Bastow CR; Tyllis TS; Fenix KA; Gregor CE; Wilson JJ; Babb R; Paton JC; Kallies A; Nutt SL; Brüstle A; Mack M; Comerford I; McColl SR Nat Commun 2017[]; 8 (ä): ä PMID28580944show ga Interleukin 17-producing ?? T (??T17) cells have unconventional trafficking characteristics, residing in mucocutaneous tissues but also homing into inflamed tissues via circulation. Despite being fundamental to ??T17-driven early protective immunity and exacerbation of autoimmunity and cancer, migratory cues controlling ??T17 cell positioning in barrier tissues and recruitment to inflammatory sites are still unclear. Here we show that ??T17 cells constitutively express chemokine receptors CCR6 and CCR2. While CCR6 recruits resting ??T17 cells to the dermis, CCR2 drives rapid ??T17 cell recruitment to inflamed tissues during autoimmunity, cancer and infection. Downregulation of CCR6 by IRF4 and BATF upon ??T17 activation is required for optimal recruitment of ??T17 cells to inflamed tissue by preventing their sequestration into uninflamed dermis. These findings establish a lymphocyte trafficking model whereby a hierarchy of homing signals is prioritized by dynamic receptor expression to drive both tissue surveillance and rapid recruitment of ??T17 cells to inflammatory lesions. äIL-17-producing ?? T cells switch migratory patterns between resting a(epmc).pdf DeepDyve Pubget Overpricing