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10.1038/ncomms15556 http://scihub22266oqcxt.onion/10.1038/ncomms15556 C5465353!5465353!28580931     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Commun 2017 ; 8 (ä): ä Nephropedia Template TP {{tp|p=28580931|t=2017. The PYRIN domain-only protein POP2 inhibits inflammasome priming and activation |pdf=|usr=}}{{28580931}} gab.com Text The PYRIN domain-only protein POP2 inhibits inflammasome priming and activation JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=28580931 #FOAvip Inflammasomes are protein platforms linking recognition of microbe, pathogen-associated and damage-associated molecular patterns by cytosolic sensory proteins to caspase-1 activation. Caspase-1 promotes pyroptotic cell death and the maturation and secretion of interleukin (IL)-1? and IL-18, which trigger inflammatory responses to clear infections and initiate wound-healing; however, excessive responses cause inflammatory disease. Inflammasome assembly requires the PYRIN domain (PYD)-containing adaptor ASC, and depends on PYD?PYD interactions. Here we show that the PYD-only protein POP2 inhibits inflammasome assembly by binding to ASC and interfering with the recruitment of ASC to upstream sensors, which prevents caspase-1 activation and cytokine release. POP2 also impairs macrophage priming by inhibiting the activation of non-canonical I?B kinase ? and I?B?, and consequently protects from excessive inflammation and acute shock in vivo. Our findings advance our understanding of the complex regulatory mechanisms that maintain a balanced inflammatory response and highlight important differences between individual POP members. Twit Text FOAVip The PYRIN domain-only protein POP2 inhibits inflammasome priming and activation ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=28580931 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28580931 #FOAvip English Wikipedia <ref>{{Cite pmid|28580931}}</ref> The PYRIN domain-only protein POP2 inhibits inflammasome priming and activation #MMPMID28580931 Ratsimandresy RA; Chu LH; Khare S; de Almeida L; Gangopadhyay A; Indramohan M; Misharin AV; Greaves DR; Perlman H; Dorfleutner A; Stehlik C Nat Commun 2017[]; 8 (ä): ä PMID28580931show ga Inflammasomes are protein platforms linking recognition of microbe, pathogen-associated and damage-associated molecular patterns by cytosolic sensory proteins to caspase-1 activation. Caspase-1 promotes pyroptotic cell death and the maturation and secretion of interleukin (IL)-1? and IL-18, which trigger inflammatory responses to clear infections and initiate wound-healing; however, excessive responses cause inflammatory disease. Inflammasome assembly requires the PYRIN domain (PYD)-containing adaptor ASC, and depends on PYD?PYD interactions. Here we show that the PYD-only protein POP2 inhibits inflammasome assembly by binding to ASC and interfering with the recruitment of ASC to upstream sensors, which prevents caspase-1 activation and cytokine release. POP2 also impairs macrophage priming by inhibiting the activation of non-canonical I?B kinase ? and I?B?, and consequently protects from excessive inflammation and acute shock in vivo. Our findings advance our understanding of the complex regulatory mechanisms that maintain a balanced inflammatory response and highlight important differences between individual POP members. äThe PYRIN domain-only protein POP2 inhibits inflammasome priming and a(epmc).pdf DeepDyve Pubget Overpricing