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10.1038/s41598-017-03285-9 http://scihub22266oqcxt.onion/10.1038/s41598-017-03285-9 C5465182!5465182 !28596518     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28596518 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Sci+Rep 2017 ; 7 (1 ): 3053 Nephropedia Template TP {{tp|p=28596518 |t=2017. Recombinant human plasma phospholipid transfer protein (PLTP) to prevent bacterial growth and to treat sepsis |pdf=|usr=}}{{28596518 }} gab.com Text Recombinant human plasma phospholipid transfer protein (PLTP) to prevent bacterial growth and to treat sepsis JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28596518 #FOAvip Although plasma phospholipid transfer protein (PLTP) has been mainly studied in the context of atherosclerosis, it shares homology with proteins involved in innate immunity. Here, we produced active recombinant human PLTP (rhPLTP) in the milk of new lines of transgenic rabbits. We successfully used rhPLTP as an exogenous therapeutic protein to treat endotoxemia and sepsis. In mouse models with injections of purified lipopolysaccharides or with polymicrobial infection, we demonstrated that rhPLTP prevented bacterial growth and detoxified LPS. In further support of the antimicrobial effect of PLTP, PLTP-knocked out mice were found to be less able than wild-type mice to fight against sepsis. To our knowledge, the production of rhPLTP to counter infection and to reduce endotoxemia and its harmful consequences is reported here for the first time. This paves the way for a novel strategy to satisfy long-felt, but unmet needs to prevent and treat sepsis. Twit Text FOAVip Recombinant human plasma phospholipid transfer protein (PLTP) to prevent bacterial growth and to treat sepsis ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28596518 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28596518 #FOAvip English Wikipedia <ref>{{Cite pmid|28596518 }}</ref> Recombinant human plasma phospholipid transfer protein (PLTP) to prevent bacterial growth and to treat sepsis #MMPMID28596518 Deckert V ; Lemaire S ; Ripoll PJ ; de Barros JP ; Labbé J ; Borgne CC ; Turquois V ; Maquart G ; Larose D ; Desroche N ; Ménétrier F ; Le Guern N ; Lebrun LJ ; Desrumaux C ; Gautier T ; Grober J ; Thomas C ; Masson D ; Houdebine LM ; Lagrost L Sci Rep 2017[Jun]; 7 (1 ): 3053 PMID28596518 show ga Although plasma phospholipid transfer protein (PLTP) has been mainly studied in the context of atherosclerosis, it shares homology with proteins involved in innate immunity. Here, we produced active recombinant human PLTP (rhPLTP) in the milk of new lines of transgenic rabbits. We successfully used rhPLTP as an exogenous therapeutic protein to treat endotoxemia and sepsis. In mouse models with injections of purified lipopolysaccharides or with polymicrobial infection, we demonstrated that rhPLTP prevented bacterial growth and detoxified LPS. In further support of the antimicrobial effect of PLTP, PLTP-knocked out mice were found to be less able than wild-type mice to fight against sepsis. To our knowledge, the production of rhPLTP to counter infection and to reduce endotoxemia and its harmful consequences is reported here for the first time. This paves the way for a novel strategy to satisfy long-felt, but unmet needs to prevent and treat sepsis. |Animals [MESH] |Anti-Infective Agents/pharmacology/*therapeutic use [MESH] |Mice [MESH] |Mice, Inbred C57BL [MESH] |Phospholipid Transfer Proteins/pharmacology/*therapeutic use [MESH] |Rabbits [MESH] |Recombinant Proteins/pharmacology/therapeutic use [MESH]Recombinant human plasma phospholipid transfer protein (PLTP) to preve(epmc).pdf DeepDyve Pubget Overpricing