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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 J+Am+Chem+Soc
2016 ; 138
(42
): 13862-13865
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Alcohols as Latent Coupling Fragments for Metallaphotoredox Catalysis:
sp(3)-sp(2) Cross-Coupling of Oxalates with Aryl Halides
#MMPMID27718570
Zhang X
; MacMillan DWC
J Am Chem Soc
2016[Oct]; 138
(42
): 13862-13865
PMID27718570
show ga
Alkyl oxalates, prepared from their corresponding alcohols, are engaged for the
first time as carbon radical fragments in metallaphotoredox catalysis. In this
report, we demonstrate that alcohols, native organic functional groups, can be
readily activated with simple oxalyl chloride to become radical precursors in a
net redox-neutral C(sp(3))-C(sp(2)) cross-coupling with a broad range of aryl
halides. This alcohol-activation coupling is successfully applied to the
functionalization of a naturally occurring steroid and the expedient synthesis of
a medicinally relevant drug lead.