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10.1111/cbdd.12631 http://scihub22266oqcxt.onion/10.1111/cbdd.12631 C5464946!5464946!26307335     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Chem+Biol+Drug+Des 2016 ; 87 (1): 5-20 Nephropedia Template TP {{tp|p=26307335|t=2016. Considerations of Protein Subpockets in Fragment-Based Drug Design |pdf=|usr=}}{{26307335}} gab.com Text Considerations of Protein Subpockets in Fragment-Based Drug Design JO: Chem Biol Drug Des http://www.kidney.de/pget.php?&tw=1&pmid=26307335 #FOAvip While the fragment-based drug design approach continues to gain importance, gaps in the tools and methods available in the identification and accurate utilization of protein subpockets have limited the scope. The importance of these features of small molecule?protein recognition is highlighted with several examples. A generalized solution for the identification of subpockets and corresponding chemical fragments remains elusive, but there are numerous advancements in methods that can be used in combination to address subpockets. Finally, additional examples of approaches that consider the relative importance of small-molecule co-dependence of protein conformations are highlighted to emphasize an increased significance of subpockets, especially at protein interfaces. Twit Text FOAVip Considerations of Protein Subpockets in Fragment-Based Drug Design ????Chem Biol Drug Des http://www.kidney.de/pget.php?&tw=1&pmid=26307335 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26307335 #FOAvip English Wikipedia <ref>{{Cite pmid|26307335}}</ref> Considerations of Protein Subpockets in Fragment-Based Drug Design #MMPMID26307335 Bartolowits M; Davisson VJ Chem Biol Drug Des 2016[Jan]; 87 (1): 5-20 PMID26307335show ga While the fragment-based drug design approach continues to gain importance, gaps in the tools and methods available in the identification and accurate utilization of protein subpockets have limited the scope. The importance of these features of small molecule?protein recognition is highlighted with several examples. A generalized solution for the identification of subpockets and corresponding chemical fragments remains elusive, but there are numerous advancements in methods that can be used in combination to address subpockets. Finally, additional examples of approaches that consider the relative importance of small-molecule co-dependence of protein conformations are highlighted to emphasize an increased significance of subpockets, especially at protein interfaces. äConsiderations of Protein Subpockets in Fragment-Based Drug Design (epmc).pdf DeepDyve Pubget Overpricing