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10.18632/oncotarget.15950 http://scihub22266oqcxt.onion/10.18632/oncotarget.15950 C5464819!5464819 !28427243     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28427243 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28427243 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Oncotarget 2017 ; 8 (20 ): 32683-32695 Nephropedia Template TP {{tp|p=28427243 |t=2017. USP22 drives colorectal cancer invasion and metastasis via epithelial-mesenchymal transition by activating AP4 |pdf=|usr=}}{{28427243 }} gab.com Text USP22 drives colorectal cancer invasion and metastasis via epithelial-mesenchymal transition by activating AP4 JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=28427243 #FOAvip Ubiquitin specific peptidase 22 (USP22), a putative cancer stem cell marker, is overexpressed in liver metastases of colorectal cancer (CRC). However, the mechanism by which USP22 promotes CRC metastasis remains largely unknown. Here, we report that USP22 and AP4 are simultaneously overexpressed during TGF-?1-induced CRC cell epithelial-mesenchymal transition (EMT). USP22 up-regulation enhances CRC cell migration and invasion and EMT-related marker and AP4 expression, but these effects are partly blocked by AP4 knockdown. In addition, USP22 binds to the promoter region of AP4 to activate its transcription. In vivo, elevated USP22 expression promotes CRC cell metastasis to the lungs in nude mice, as evidenced by the fact that CRC metastatic nodules stain deeply positive for USP22 and AP4. In human CRC tissues, the genes encoding USP22 and AP4 are overexpressed in metastatic liver lesions compared with primary cancer tissues, and their overexpression is significantly associated with poor CRC patient survival. These findings indicate that USP22 and AP4 may serve as prognostic markers for predicting the risk of developing distant metastases in CRC. Twit Text FOAVip USP22 drives colorectal cancer invasion and metastasis via epithelial-mesenchymal transition by activating AP4 ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=28427243 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28427243 #FOAvip English Wikipedia <ref>{{Cite pmid|28427243 }}</ref> USP22 drives colorectal cancer invasion and metastasis via epithelial-mesenchymal transition by activating AP4 #MMPMID28427243 Li Y ; Yang Y ; Li J ; Liu H ; Chen F ; Li B ; Cui B ; Liu Y Oncotarget 2017[May]; 8 (20 ): 32683-32695 PMID28427243 show ga Ubiquitin specific peptidase 22 (USP22), a putative cancer stem cell marker, is overexpressed in liver metastases of colorectal cancer (CRC). However, the mechanism by which USP22 promotes CRC metastasis remains largely unknown. Here, we report that USP22 and AP4 are simultaneously overexpressed during TGF-?1-induced CRC cell epithelial-mesenchymal transition (EMT). USP22 up-regulation enhances CRC cell migration and invasion and EMT-related marker and AP4 expression, but these effects are partly blocked by AP4 knockdown. In addition, USP22 binds to the promoter region of AP4 to activate its transcription. In vivo, elevated USP22 expression promotes CRC cell metastasis to the lungs in nude mice, as evidenced by the fact that CRC metastatic nodules stain deeply positive for USP22 and AP4. In human CRC tissues, the genes encoding USP22 and AP4 are overexpressed in metastatic liver lesions compared with primary cancer tissues, and their overexpression is significantly associated with poor CRC patient survival. These findings indicate that USP22 and AP4 may serve as prognostic markers for predicting the risk of developing distant metastases in CRC. |Animals [MESH] |Basic Helix-Loop-Helix Leucine Zipper Transcription Factors/*genetics/*metabolism [MESH] |Cell Line, Tumor [MESH] |Cell Movement [MESH] |Colorectal Neoplasms/genetics/metabolism/*pathology [MESH] |DNA-Binding Proteins [MESH] |Epithelial-Mesenchymal Transition [MESH] |Female [MESH] |Gene Expression Regulation, Neoplastic [MESH] |HCT116 Cells [MESH] |Humans [MESH] |Liver Neoplasms/genetics/metabolism/*pathology/*secondary [MESH] |Male [MESH] |Mice [MESH] |Mice, Nude [MESH] |Neoplasm Invasiveness [MESH] |Neoplasm Transplantation [MESH] |Prognosis [MESH] |Promoter Regions, Genetic [MESH] |RNA-Binding Proteins [MESH] |Thiolester Hydrolases/*metabolism [MESH] |Transforming Growth Factor beta1/pharmacology [MESH] |Ubiquitin Thiolesterase [MESH]USP22 drives colorectal cancer invasion and metastasis via epithelial-(epmc).pdf DeepDyve Pubget Overpricing