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10.18632/oncotarget.15808 http://scihub22266oqcxt.onion/10.18632/oncotarget.15808 C5464806!5464806!28430645     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Oncotarget 2017 ; 8 (20): 32523-35 Nephropedia Template TP {{tp|p=28430645|t=2017. Midkine promotes hepatocellular carcinoma metastasis by elevating anoikis resistance of circulating tumor cells |pdf=|usr=}}{{28430645}} gab.com Text Midkine promotes hepatocellular carcinoma metastasis by elevating anoikis resistance of circulating tumor cells JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=28430645 #FOAvip Midkine is overexpressed in hepatocellular carcinoma (HCC) and plays a role in tumor progression, but less is known about its role in resistance of circulating tumor cells (CTCs) to anoikis which leading to recurrence and metastasis. The aim of the present study was to analyze whether midkine was associated with HCC progression with anoikis resistance. We found that cultured HCC cells were more resistant to anoikis, which paralleled midkine expression, and midkine treatment significantly inhibited anoikis in a dose-dependent manner. Furthermore, in in vitro and in vivo assays, knockdown of midkine resulted in significant sensitivity to anoikis, decreased cell survival and significantly decreased tumor occurrence rate. Patients with midkine-elevated HCC had higher CTC counts and less apoptotic CTCs, as well as significantly higher recurrence rate and shorter recurrence-free interval. To understand the molecular mechanism underlying the midkine with HCC progression, we performed in vitro and in vivo studies. We found that midkine plays an important role in enhancement of HCC cell resistance to anoikis, thereby promoting subsequent metastasis. Activation of PI3K/Akt/NF-?B/TrkB signaling by midkine-activated anaplastic lymphomakinase (ALK) is responsible for anoikis resistance. Twit Text FOAVip Midkine promotes hepatocellular carcinoma metastasis by elevating anoikis resistance of circulating tumor cells ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=28430645 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28430645 #FOAvip English Wikipedia <ref>{{Cite pmid|28430645}}</ref> Midkine promotes hepatocellular carcinoma metastasis by elevating anoikis resistance of circulating tumor cells #MMPMID28430645 Sun B; Hu C; Yang Z; Zhang X; Zhao L; Xiong J; Ma J; Chen L; Qian H; Luo X; Shi L; Li J; Cheng X; Yin Z Oncotarget 2017[May]; 8 (20): 32523-35 PMID28430645show ga Midkine is overexpressed in hepatocellular carcinoma (HCC) and plays a role in tumor progression, but less is known about its role in resistance of circulating tumor cells (CTCs) to anoikis which leading to recurrence and metastasis. The aim of the present study was to analyze whether midkine was associated with HCC progression with anoikis resistance. We found that cultured HCC cells were more resistant to anoikis, which paralleled midkine expression, and midkine treatment significantly inhibited anoikis in a dose-dependent manner. Furthermore, in in vitro and in vivo assays, knockdown of midkine resulted in significant sensitivity to anoikis, decreased cell survival and significantly decreased tumor occurrence rate. Patients with midkine-elevated HCC had higher CTC counts and less apoptotic CTCs, as well as significantly higher recurrence rate and shorter recurrence-free interval. To understand the molecular mechanism underlying the midkine with HCC progression, we performed in vitro and in vivo studies. We found that midkine plays an important role in enhancement of HCC cell resistance to anoikis, thereby promoting subsequent metastasis. Activation of PI3K/Akt/NF-?B/TrkB signaling by midkine-activated anaplastic lymphomakinase (ALK) is responsible for anoikis resistance. äMidkine promotes hepatocellular carcinoma metastasis by elevating anoi(epmc).pdf DeepDyve Pubget Overpricing