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10.7554/eLife.23190 http://scihub22266oqcxt.onion/10.7554/eLife.23190 C5464771!5464771!28594327     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       eLife 2017 ; 6 (ä): ä Nephropedia Template TP {{tp|p=28594327|t=2017. Different TCR-induced T lymphocyte responses are potentiated by stiffness with variable sensitivity |pdf=|usr=}}{{28594327}} gab.com Text Different TCR-induced T lymphocyte responses are potentiated by stiffness with variable sensitivity JO: eLife http://www.kidney.de/pget.php?&tw=1&pmid=28594327 #FOAvip T cells are mechanosensitive but the effect of stiffness on their functions is still debated. We characterize herein how human primary CD4+ T cell functions are affected by stiffness within the physiological Young?s modulus range of 0.5 kPa to 100 kPa. Stiffness modulates T lymphocyte migration and morphological changes induced by TCR/CD3 triggering. Stiffness also increases TCR-induced immune system, metabolism and cell-cycle-related genes. Yet, upon TCR/CD3 stimulation, while cytokine production increases within a wide range of stiffness, from hundreds of Pa to hundreds of kPa, T cell metabolic properties and cell cycle progression are only increased by the highest stiffness tested (100 kPa). Finally, mechanical properties of adherent antigen-presenting cells modulate cytokine production by T cells. Together, these results reveal that T cells discriminate between the wide range of stiffness values found in the body and adapt their responses accordingly.DOI:http://dx.doi.org/10.7554/eLife.23190.001 Twit Text FOAVip Different TCR-induced T lymphocyte responses are potentiated by stiffness with variable sensitivity ????eLife http://www.kidney.de/pget.php?&tw=1&pmid=28594327 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28594327 #FOAvip English Wikipedia <ref>{{Cite pmid|28594327}}</ref> Different TCR-induced T lymphocyte responses are potentiated by stiffness with variable sensitivity #MMPMID28594327 Saitakis M; Dogniaux S; Goudot C; Bufi N; Asnacios S; Maurin M; Randriamampita C; Asnacios A; Hivroz C eLife 2017[]; 6 (ä): ä PMID28594327show ga T cells are mechanosensitive but the effect of stiffness on their functions is still debated. We characterize herein how human primary CD4+ T cell functions are affected by stiffness within the physiological Young?s modulus range of 0.5 kPa to 100 kPa. Stiffness modulates T lymphocyte migration and morphological changes induced by TCR/CD3 triggering. Stiffness also increases TCR-induced immune system, metabolism and cell-cycle-related genes. Yet, upon TCR/CD3 stimulation, while cytokine production increases within a wide range of stiffness, from hundreds of Pa to hundreds of kPa, T cell metabolic properties and cell cycle progression are only increased by the highest stiffness tested (100 kPa). Finally, mechanical properties of adherent antigen-presenting cells modulate cytokine production by T cells. Together, these results reveal that T cells discriminate between the wide range of stiffness values found in the body and adapt their responses accordingly.DOI:http://dx.doi.org/10.7554/eLife.23190.001 äDifferent TCR-induced T lymphocyte responses are potentiated by stiffn(epmc).pdf DeepDyve Pubget Overpricing