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10.7554/eLife.23190 http://scihub22266oqcxt.onion/10.7554/eLife.23190 C5464771!5464771 !28594327     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28594327 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       Elife 2017 ; 6 (?): ? Nephropedia Template TP {{tp|p=28594327 |t=2017. Different TCR-induced T lymphocyte responses are potentiated by stiffness with variable sensitivity |pdf=|usr=}}{{28594327 }} gab.com Text Different TCR-induced T lymphocyte responses are potentiated by stiffness with variable sensitivity JO: Elife http://www.kidney.de/pget.php?&tw=1&pmid=28594327 #FOAvip T cells are mechanosensitive but the effect of stiffness on their functions is still debated. We characterize herein how human primary CD4(+) T cell functions are affected by stiffness within the physiological Young's modulus range of 0.5 kPa to 100 kPa. Stiffness modulates T lymphocyte migration and morphological changes induced by TCR/CD3 triggering. Stiffness also increases TCR-induced immune system, metabolism and cell-cycle-related genes. Yet, upon TCR/CD3 stimulation, while cytokine production increases within a wide range of stiffness, from hundreds of Pa to hundreds of kPa, T cell metabolic properties and cell cycle progression are only increased by the highest stiffness tested (100 kPa). Finally, mechanical properties of adherent antigen-presenting cells modulate cytokine production by T cells. Together, these results reveal that T cells discriminate between the wide range of stiffness values found in the body and adapt their responses accordingly. Twit Text FOAVip Different TCR-induced T lymphocyte responses are potentiated by stiffness with variable sensitivity ????Elife http://www.kidney.de/pget.php?&tw=1&pmid=28594327 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28594327 #FOAvip English Wikipedia <ref>{{Cite pmid|28594327 }}</ref> Different TCR-induced T lymphocyte responses are potentiated by stiffness with variable sensitivity #MMPMID28594327 Saitakis M ; Dogniaux S ; Goudot C ; Bufi N ; Asnacios S ; Maurin M ; Randriamampita C ; Asnacios A ; Hivroz C Elife 2017[Jun]; 6 (?): ? PMID28594327 show ga T cells are mechanosensitive but the effect of stiffness on their functions is still debated. We characterize herein how human primary CD4(+) T cell functions are affected by stiffness within the physiological Young's modulus range of 0.5 kPa to 100 kPa. Stiffness modulates T lymphocyte migration and morphological changes induced by TCR/CD3 triggering. Stiffness also increases TCR-induced immune system, metabolism and cell-cycle-related genes. Yet, upon TCR/CD3 stimulation, while cytokine production increases within a wide range of stiffness, from hundreds of Pa to hundreds of kPa, T cell metabolic properties and cell cycle progression are only increased by the highest stiffness tested (100 kPa). Finally, mechanical properties of adherent antigen-presenting cells modulate cytokine production by T cells. Together, these results reveal that T cells discriminate between the wide range of stiffness values found in the body and adapt their responses accordingly. |*Mechanical Phenomena [MESH] |CD4-Positive T-Lymphocytes/*immunology/*physiology [MESH] |Cells, Cultured [MESH] |Cytokines/metabolism [MESH] |Humans [MESH] |Receptors, Antigen, T-Cell/*metabolism [MESH]Different TCR-induced T lymphocyte responses are potentiated by stiffn(epmc).pdf DeepDyve Pubget Overpricing