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10.12659/AJCR.903679 http://scihub22266oqcxt.onion/10.12659/AJCR.903679 C5464756!5464756!28566677     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Am+J+Case+Rep 2017 ; 18 (ä): 611-6 Nephropedia Template TP {{tp|p=28566677|t=2017. High-Grade Transformation in a Splenic Marginal Zone Lymphoma with a Cerebral Manifestation |pdf=|usr=}}{{28566677}} gab.com Text High-Grade Transformation in a Splenic Marginal Zone Lymphoma with a Cerebral Manifestation JO: Am J Case Rep http://www.kidney.de/pget.php?&tw=1&pmid=28566677 #FOAvip Patient: Female, 31Final Diagnosis: Histological transformation of splenic low-grade lymphomaSymptoms: Fatigue ? night sweatsMedication: ?Clinical Procedure: Intravenous methylprednisolone followed by high-dose methotrexateSpecialty: HematologyObjective:: Unusual clinical course Background:: Splenic marginal zone lymphomas (SMZLs) are generally uncommon, indolent lymphomas that typically affect older adults, but the development of the transformation to high-grade lymphoma may occur in a small proportion of patients and represents a rare event with blastic cell infiltration in the lymph nodes and bone marrow. Case Report:: Here, we present a young adult patient who was diagnosed with a SMZL and developed a high-grade transformation to diffuse large B cell lymphoma (DLBCL) with central nervous system involvement. The patient was a 31-year-old woman whose hematologic medical history began with severe anemia and thrombocytopenia associated with atypical lymphoid infiltrate in the bone marrow and massive splenomegaly. A splenectomy was performed and revealed the SMZL. She was first treated with the CHOP regimen (cyclophosphamide, doxorubicin, vincristine, and prednisone) and subsequently with the R-FMD regimen (rituximab, fludarabine, mitoxantrone, and dexamethasone) because the peripheral blood leukocytes were remarkably increased postoperatively. Six months after the splenectomy, she complained of headaches. A magnetic resonance imaging scan of her brain revealed intracerebral tumorous lesions from which a biopsy was taken. On morphological and immunohistochemical examination, the tumor fulfilled the criteria for a DLBCL. Treatment with pulse-dose intravenous methylprednisolone followed by high-dose methotrexate was promptly initiated, but the patient?s condition continued to deteriorate and she died of the disease 13 months after the splenectomy. Conclusions:: Although there is a general tendency for SMZL to display low aggressiveness, central nervous system involvement associated with a histological transformation to high-grade lymphoma, as presented here, can occur in advanced stage of the disease. Twit Text FOAVip High-Grade Transformation in a Splenic Marginal Zone Lymphoma with a Cerebral Manifestation ????Am J Case Rep http://www.kidney.de/pget.php?&tw=1&pmid=28566677 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28566677 #FOAvip English Wikipedia <ref>{{Cite pmid|28566677}}</ref> High-Grade Transformation in a Splenic Marginal Zone Lymphoma with a Cerebral Manifestation #MMPMID28566677 Gao X; Li J; Lin J; Liu D; Yu L; Wang Q Am J Case Rep 2017[]; 18 (ä): 611-6 PMID28566677show ga Patient: Female, 31Final Diagnosis: Histological transformation of splenic low-grade lymphomaSymptoms: Fatigue ? night sweatsMedication: ?Clinical Procedure: Intravenous methylprednisolone followed by high-dose methotrexateSpecialty: HematologyObjective:: Unusual clinical course Background:: Splenic marginal zone lymphomas (SMZLs) are generally uncommon, indolent lymphomas that typically affect older adults, but the development of the transformation to high-grade lymphoma may occur in a small proportion of patients and represents a rare event with blastic cell infiltration in the lymph nodes and bone marrow. Case Report:: Here, we present a young adult patient who was diagnosed with a SMZL and developed a high-grade transformation to diffuse large B cell lymphoma (DLBCL) with central nervous system involvement. The patient was a 31-year-old woman whose hematologic medical history began with severe anemia and thrombocytopenia associated with atypical lymphoid infiltrate in the bone marrow and massive splenomegaly. A splenectomy was performed and revealed the SMZL. She was first treated with the CHOP regimen (cyclophosphamide, doxorubicin, vincristine, and prednisone) and subsequently with the R-FMD regimen (rituximab, fludarabine, mitoxantrone, and dexamethasone) because the peripheral blood leukocytes were remarkably increased postoperatively. Six months after the splenectomy, she complained of headaches. A magnetic resonance imaging scan of her brain revealed intracerebral tumorous lesions from which a biopsy was taken. On morphological and immunohistochemical examination, the tumor fulfilled the criteria for a DLBCL. Treatment with pulse-dose intravenous methylprednisolone followed by high-dose methotrexate was promptly initiated, but the patient?s condition continued to deteriorate and she died of the disease 13 months after the splenectomy. Conclusions:: Although there is a general tendency for SMZL to display low aggressiveness, central nervous system involvement associated with a histological transformation to high-grade lymphoma, as presented here, can occur in advanced stage of the disease. äHigh-Grade Transformation in a Splenic Marginal Zone Lymphoma with a C(epmc).pdf DeepDyve Pubget Overpricing