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10.1111/cen3.12341 http://scihub22266oqcxt.onion/10.1111/cen3.12341 C5464738!5464738!28603559     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Clin+Exp+Neuroimmunol 2016 ; 7 (4): 330-45 Nephropedia Template TP {{tp|p=28603559|t=2016. Three immune-mediated disease models induced by Theiler?s virus: Multiple sclerosis, seizures and myocarditis |pdf=|usr=}}{{28603559}} gab.com Text Three immune-mediated disease models induced by Theiler s virus: Multiple sclerosis, seizures and myocarditis JO: Clin Exp Neuroimmunol http://www.kidney.de/pget.php?&tw=1&pmid=28603559 #FOAvip Theiler?s murine encephalomyelitis virus (TMEV) infection has been used as a viral model for multiple sclerosis (MS), as TMEV can induce chronic inflammatory demyelinating lesions with viral persistence in the spinal cord of SJL/J mice. In contrast, when C57BL/6 mice are infected with TMEV, the mice can clear the virus from the central nervous system (CNS), without viral persistence or demyelination, but develop seizures and hippocampal sclerosis, which has been used as a viral model for seizures/epilepsy. In the two TMEV-induced CNS disease models, not only viral infection, but also immune responses contribute to the pathogenesis. Interestingly, acquired immunity plays an effector role in the MS model, whereas innate immunity appears to contribute to the development of seizures. Recently, we have established the third TMEV-induced disease model, a mouse model for viral myocarditis, using C3H mice. TMEV-induced myocarditis is a triphasic disease, which mimics human myocarditis; phase I, mediated by viral replication in the heart and innate immunity; phase II, mediated by acquired immunity; and phase III, resulted from cardiac fibrosis. The genetic susceptibility to the aforementioned three models (MS, seizures and myocarditis) differs among mouse strains. We have compared and contrasted the three models induced by one single pathogen, TMEV, particularly in regard to the roles of T helper cells and natural killer T cells, which will give an insight into how interactions between the immune system and the host?s genetic background determine the tissue tropism of virus and the development of virus-induced organ-specific immunopathology. Twit Text FOAVip Three immune-mediated disease models induced by Theiler s virus: Multiple sclerosis, seizures and myocarditis ????Clin Exp Neuroimmunol http://www.kidney.de/pget.php?&tw=1&pmid=28603559 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28603559 #FOAvip English Wikipedia <ref>{{Cite pmid|28603559}}</ref> Three immune-mediated disease models induced by Theiler?s virus: Multiple sclerosis, seizures and myocarditis #MMPMID28603559 Tsunoda I; Sato F; Omura S; Fujita M; Sakiyama N; Park AM Clin Exp Neuroimmunol 2016[Nov]; 7 (4): 330-45 PMID28603559show ga Theiler?s murine encephalomyelitis virus (TMEV) infection has been used as a viral model for multiple sclerosis (MS), as TMEV can induce chronic inflammatory demyelinating lesions with viral persistence in the spinal cord of SJL/J mice. In contrast, when C57BL/6 mice are infected with TMEV, the mice can clear the virus from the central nervous system (CNS), without viral persistence or demyelination, but develop seizures and hippocampal sclerosis, which has been used as a viral model for seizures/epilepsy. In the two TMEV-induced CNS disease models, not only viral infection, but also immune responses contribute to the pathogenesis. Interestingly, acquired immunity plays an effector role in the MS model, whereas innate immunity appears to contribute to the development of seizures. Recently, we have established the third TMEV-induced disease model, a mouse model for viral myocarditis, using C3H mice. TMEV-induced myocarditis is a triphasic disease, which mimics human myocarditis; phase I, mediated by viral replication in the heart and innate immunity; phase II, mediated by acquired immunity; and phase III, resulted from cardiac fibrosis. The genetic susceptibility to the aforementioned three models (MS, seizures and myocarditis) differs among mouse strains. We have compared and contrasted the three models induced by one single pathogen, TMEV, particularly in regard to the roles of T helper cells and natural killer T cells, which will give an insight into how interactions between the immune system and the host?s genetic background determine the tissue tropism of virus and the development of virus-induced organ-specific immunopathology. äThree immune-mediated disease models induced by Theiler?s virus: Multi(epmc).pdf DeepDyve Pubget Overpricing